Dr Elissa Deenick

Lab Head - Lymphocyte Signalling and Activation

Senior Research Officer

Elissa undertook her PhD with Dr Phil Hodgkin at the Centenary Institute/University of Sydney. Following her PhD she moved to Canada to take up a postdoctoral position in the lab of Dr Pam Ohashi at the University of Toronto looking at the signalling pathways controlling T cell activation and tolerance.

In 2007 she returned to Sydney to work at the Garvan Institute, where she is currently a Lab Head in the Immunology Research Program. Here she has continued her interests in lymphocyte activation and differentiation, using both mouse models and primary human cells to investigate the signals that control these processes.


PhD University of Sydney - Australia
BMedSci (Hons) University of Sydney - Australia

Selected Publications

A Kane, A Lau, R Brink, SG Tangye, EK Deenick. B-cell specific STAT3-deficiency: insight into the molecular basis of Autosomal Dominant Hyper IgE Syndrome. J Allergy Clin Immunol (November 2016) 138:1455-1458

S Okada, Markle JG, Deenick EK, Mele F, Averbuch D, Lagos M, Alzahrani M, Al-Muhsen S, Halwani R, Ma CS, Wong N, Soudais C, Henderson L, Marzouqa H, Shamma J, Gonzalez M, Martinez-Baricarte R, Okada C, Avery DT, Latorre D, Deswarte C, Jabot-Hanin F, Torrado E, Fountain J, Belkadi A, Itan Y, Boisson B, Migaud M, Lindestam Arlehamn CS, Sette A, Breton S, McCluskey J, Rossjohn J, de Villartay J-P, Moshous D, Hambleton S, Latour S, Arkwright P, Picard C, Lantz O, Engelhard D, Kobayashi M, Abel L, Cooper AM, Notarangelo LD, Boisson-Dupuis S, Puel A, Sallusto F, Bustamante J, Tangye SG, Casanova JL. Impairment of IL-17 immunity to Candida and IFN-g immunity to Mycobacterium in humans with inherited RORgT deficiency. Science (Published online 10 July 2015) 349: 606.13

Ma C, Wong N, Rao G, Avery D, Torpy J, Bustamante J, Okada S, Stoddard J, Deenick EK, Pelham S, Boisson-Dupuis S, Puel A, Kobayashi M, Arkwright P, Kilic SS, El Baghdadi J, Nonoyama S, Minegishi Y, Mahdaviani SA, Mansouri D, Bousfiha A, French M, Hsu P, Campbell D, Stormon M, Wong M, Adelstein S, Smart J, Fulcher D, Cook M, Phan TG, Stepensky P, Boztug K, Ikincioğullari A, Beier R, Ziegler J, Gray P, Picard C, Grimbacher B, Warnatz K, Holland S, Casanova JL, Uzel G, Tangye Sfg. Monogenic mutations differentially impact the quantity and quality of T follicular helper cells in human primary immunodeficiencies. J Allergy Clin Immunol (Published online July 8 2015).  136: 10.1016

S Pelham, H Lenthall, EK Deenick, SG Tangye. Elucidating the effects of disease-1 causing mutations on STAT3 function in autosomal dominant hyper-IgE syndrome. J Allergy Clin Immunol (October 2016) 138:1210-1213

Wilson RP, Ives ML, Rao G, Lau A, Payne K, Kobayashi M, Arkwright PD, Peake J, Wong M, Adelstein S, Smart JM, French MA, Fulcher DA, Picard C, Bustamante J, Boisson-Dupuis S, Gray P, Stepensky P, Warnatz K, Freeman AF, Rossjohn J, McCluskey J, Holland SM, Casanova J-L, Uzel G, Ma CS, Tangye SG, and Deenick EK.  STAT3 is a critical cell intrinsic regulator of human unconventional T cell numbers and function. J Exp Med  212: 855-864. 2015

Suan D, Nguyen A, Moran I, Bourne K, Hermes JR, Arshi M, Hampton HR, Tomura M, Miwa Y, Kelleher AD, Kaplan W, Deenick EK, Tangye SG, Brink R, Chtanova T, and Phan TG (2015) T follicular helper cells have distinct modes of migration and molecular signatures in naive and memory immune responses. Immunity 42: 704-18. 2015

Ma, C, Wong N, Avery DT, Torpy J, Stoddard JL, Kobayashi M, Deenick EK, Casanova, JL, Uze G, Tangye, SG. Determining the Molecular Requirements for Generating Human T Follicular Helper (Tfh) Cells. J Clin Immunol 32:S458-S5459. 2014

Kane A, Deenick EK, Ma CS, Cook MC, Uzel G, Tangye SG. (2014). STAT3 is a central regulator of lymphocyte differentiation and function. Curr Opin Immunol 28C, 49-57. 2014

Ma CS,  Deenick EK. (2014). Human T follicular helper (Tfh) cells and disease. Immunol Cell Biol 92, 64-71. 2014

Lucas CL, Kuehn HS, Zhao F, Niemele JE, Deenick EK, Palendira U, UzelG. (2014). Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency. Nat Immunol 15, 88-97. 2014

Kuehn, HS, Ouyang W,  Lo B, Deenick  EK, Niemela  JE, Avery DT, Uzel, G. (2014). Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4. Science. 2014

Ives, ML, Ma, C.S., Palendira, U., Chan, A., Bustamante, J., Boisson-Dupuis, S., . . . Deenick, EK. (2013). Signal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8(+) T-cell memory formation and function. J Allergy Clin Immunol 132, 400-411.e409. 2014

Berglund, L.J., Avery, D.T., Ma, C.S., Moens, L., Deenick, E.K., Bustamante, J., . . . Tangye, SG. (2013). IL-21 signalling via STAT3 primes human naive B cells to respond to IL-2 to enhance their differentiation into plasmablasts. Blood 122, 3940-3950. 2013

Tangye, S.G., Ma, C.S., Brink, R., and Deenick, E.K. (2013). The good, the bad and the ugly - TFH cells in human health and disease. Nat Rev Immunol 13, 412-426. 2013

Deenick, E.K., Avery, D.T., Chan, A., Berglund, L.J., Ives, M.L., Moens, L., . . . Tangye, S.G. (2013). Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells. J Exp Med 210, 2739-2753. 2013

Ma, C.S., Deenick, E.K., Batten, M., and Tangye, S.G. (2012). The origins, function, and regulation of T follicular helper cells. J Exp Med 209, 1241-1253. 2012

Tangye, S.G., Deenick, E.K., Palendira, U., and Ma, C.S. (2012). T cell-B cell interactions in primary immunodeficiencies. Ann N Y Acad Sci 1250, 1-13. 2012

Deenick, E.K., and Ma, C.S. (2011). The regulation and role of T follicular helper cells in immunity. Immunology 134, 361-367.

Ma, C.S., and Deenick, E.K. (2011). The role of SAP and SLAM family molecules in the humoral immune response. Ann N Y Acad Sci 1217, 32-44.

Deenick, E.K., Ma, C.S., Brink, R., and Tangye, S.G. (2011). Regulation of T follicular helper cell formation and function by antigen presenting cells. Curr Opin Immunol 23, 111-118.

Deenick, E.K., Elford, A.R., Pellegrini, M., Hall, H., Mak, T.W., and Ohashi, P.S. (2010). c-Rel but not NF-kappaB1 is important for T regulatory cell development. Eur J Immunol 40, 677-681.

Deenick, E.K., Po, L., Chapatte, L., Murakami, K., Lu, Y.-C., Elford, A.R., . . . Ohashi, P.S. (2010). c-Rel phenocopies PKCtheta but not Bcl-10 in regulating CD8+ T-cell activation versus tolerance. Eur J Immunol 40, 867-877.

Ma, C.S., Tangye, S.G., and Deenick, E.K. (2010). Human Th9 cells: inflammatory cytokines modulate IL-9 production through the induction of IL-21. Immunol Cell Biol 88, 621-623.

Deenick, E.K., Chan, A., Ma, C.S., Gatto, D., Schwartzberg, P.L., Brink, R., and Tangye, S.G. (2010). Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling. Immunity 33, 241-253.

Avery, D.T., Deenick, E.K., Ma, C.S., Suryani, S., Simpson, N., Chew, G.Y., . . . Tangye, S.G. (2010). B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans. J Exp Med 207, 155-171.

Dr Elissa Deenick