A/Prof Shane Grey

Lab Head - Transplantation Immunology

NHMRC Senior Research Fellow

Conjoint/Adjunct Role(s)

Associate Professor, St Vincent's Clinical School, Faculty of Medicine, UNSW, New South Wales Australia
Associate Professor, Discipline of Medicine, Faculty of Health Sciences, University of Adelaide, South Australia
Visiting Scientist & Consultant, Central Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, South Australia

Shane received his PhD immunology training at Monash University and his post-doctoral training as a transplant immunologist at Harvard Medical School, USA. Shane later became involved in islet transplantation and type I diabetes research though the JDRF Islet Transplant Center at Harvard in the late 1990’s.

In 2000 he received a JDRF Career Development Award to establish a research program aiming to understand how islet beta cells die; and in 2001 was appointed as Assistant Professor in Surgery at Harvard Medical School. In 2003 Shane received a NSW BioFirst Award and was recruited back to Australia to the Garvan Institute. In 2007, Shane was awarded as a Key Opinion Leader (KOL) in transplantation by The Transplantation Society International. In 2010 Shane received a JDRF- Macquarie Group Foundation Innovation Award for his work in T1D.

Shane is the head of a transplant immunology research team at the Garvan; a lead investigator on Australia's first clinical islet transplant program at Westmead; Program Director of a national NHMRC/JDRF research program for T1D and a founder of the Australian Islet Study Group.

Research Interests

Type 1 diabetes
Transplant immunology
Islet inflammation
Nuclear Factor kappaB
T1D Genomics

Awards and Honours

2000 JDRF Career Development Award
2001 Assistant Professor in Surgery, Harvard Medical School.
2003 NSW-BioFirst Award
2003 Senior Research Fellow, Garvan Medical Research Institute, Sydney, Australia.
2005 Mary Jane Kugel Award, JDRF New York
2007 “Key Opinion Leader (KOL)” award in transplantation – The international Transplantation Society (TTS)
2008 Mary Jane Kugel Award, JDRF New York
2009 Australian Research Council (ARC) Future Fellow Award
2010 NHMRC Senior Research Fellowship
2010 JDRF and Macquarie Group Foundation Diabetes Research Innovation Award
2011 Associate Professor, Faculty of Medicine, UNSW, Sydney, Australia
2012 TSANZ “Ian McKenzie Prize” – for outstanding contributions in Transplantation


1985 - BSc La Trobe University, Melbourne - Australia
1988 - BSc (Honours), Monash University, Melbourne - Australia
1991-1995 - PhD, Monash University, Melbourne - Australia
1996-99 Post Doctoral Training, Harvard Medical School, Boston
2000 Instructor in Surgery, Harvard Medical School, Boston
2001-2003 Assistant Professor in Surgery, Harvard Medical School, Boston

Selected Publications

Grey ST. Fattening Up Allograft Rejection. Transplantation. 2016 May

Chandrakanthan V, Yeola A, Kwan JC, Oliver RA, Qiao Q, Kang YC, Zarzour P, Beck D, Boelen L, Unnikrishnan A, Villanueva JE, Nunez AC, Knezevic K, Palu C, Nasrallah R, Carnell M, Macmillan A, Whan R, Yu Y, Hardy P, Grey ST, Gladbach A, Delerue F, Ittner L, Mobbs R, Walkley CR, Purton LE, Ward RL, Wong JW, Hesson LB, Walsh W, Pimanda JE. PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells. Porc Natl Acad Sci USA. 2016 Apr 19

Coates PT, Grey ST. Finding a New Home for Islet Cell Transplants. Transplantation. 2016 Apr 16

Grey ST. Antigen-encoding bone marrow terminates islet-directed memory CD8+ T-cell responses to alleviate islet transplant rejection. Diabetes. 2016 Mar 9

Tulles SG, Grey ST, Issa F. Awards in Transplantation Science Recognize the Best Manuscripts Published in Transplantation. Transplantation. 2016 Feb

Erami Z, Herrmann D, Warren SC, Nobis M, McGhee EJ, Lucas MC, Leung W, Reischmann N, Mrowinska A, Schwarz JP, Kadir S, Conway JR, Vennin C, Karim SA, Campbell AD, Gallego-Ortega D, Magenau A, Murphy KJ, Ridgway RA, Law AM, Walters SN, Grey ST, Croucher DR, Zhang L, Herzog H, Hardeman EC, Gunning PW, Ormandy CJ, Evans TR, Strathdee D, Sansom OJ, Morton JP, Anderson KI, Timpson P.  Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue. Cell Rep. 2016 Jan 5

Malle EK, Zammit NW, Walters SN, Koay YC, Wu J, Tan BM, Villanueva JE, Brink R, Loudovaris T, Cantley J, McAlpine SR, Hesselson D, Grey ST. Nuclear factor kappaB-inducing kinase activation as a mechanism of pancreatic β cell failure in obesity. J Exp Med. 2015 Jun 29 Released with Commentary: http://jem.rupress.org/content/212/8/1140.2?etoc

Sivanathan KN, Rojas-Canales DM, Hope CM, Krishnan R, Carroll RP, Gronthos S, *Grey ST, *Coates PT. Interleukin-17A-Induced Human Mesenchymal Stem Cells Are Superior Modulators of Immunological Function. Stem Cells. 2015 Jun 2. *Co-senior authors.

Villanueva, J.E.; Malle, E.K.; Gardam, S.; Silveira, P.A.; Zammit, N.W.; Walters, S.N.; Brink, R.; Grey S.T. TRAF2 regulates peripheral CD8+ T-cell and NKT-cell homeostasis by modulating sensitivity to IL-15. Eur J Immunol 2015; 45(6):1820-31

Roden D, Grey ST.  Telling the tiger by its stripes: mapping the genomics of kidney graft tolerance in real time. Kidney Int 2015; 87(5): 875-7

Stacey. N. Walters, Kylie. E. Webster, Stephen Daley and Shane T. Grey. A role for intrathymic B cells in the generation of natural Tregs. J. Immunol. 2014 Jul 1;193(1):170-6

Mariño E, Walters SN, Villanueva JE, Richards JL, Mackay CR, Grey ST. BAFF regulates activation of self-reactive T cells through B-cell dependent mechanisms and mediates protection in NOD mice. Eur J Immunol. 2014 Apr;44(4):983-93. 

B. M. Tan, N. W. Zammit, A. O. Yam, R. Slattery, S. N. Walters, E. Malle and S. T. Grey. Baculoviral inhibitors of apoptosis repeat containing (BIRC) proteins fine-tune TNF-induced nuclear factor kB and c-Jun N-terminal kinase signalling in mouse pancreatic beta cells. Diabetologia 2013; 56(3):520-32.

Marino, E, Tan, B, Binge, L, Mackay CR, Grey ST B-cell cross-presentation of autologous antigen precipitates diabetes. Diabetes 2012; 61(11) 2893-905

Cowley MJ, Weinberg A, Zammit N, Walters SN, Hawthorne WJ, Loudovaris T, Thomas H, Kay T, Gunton JE, Alexander SI, Kaplan W, Chapman J, O'Connell PJ, Grey ST. Human islets express a marked pro-inflammatory molecular signature prior to transplantation. Cell Transplant. 2012; 21(9):2063-78.

Marino, E., P. A. Silveira, J. Stolp, and S. T. Grey. 2010. B-cell directed therapies in Type 1 Diabetes. Trends in Immunology. 2011 Jun;32(6):287-94.

Marino E, Villanueva J, Walters S, Liuwantara D, Mackay F, Grey ST. CD4(+)CD25(+) T-cells control autoimmunity in the absence of B-cells. Diabetes 2009; 58(7):1568-77.

Webster KE, Walters S, Kohler RE, Mrkvan T, Boyman O, Surh CD, Grey ST, Sprent J. In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression. J Exp Med 2009; 206(4):751-60.

Walters S, Webster KE, Sutherland A, Gardam S, Groom J, Liuwantara D, Mariño E, Thaxton J, Weinberg A, Mackay F, Brink R, Sprent J, Grey ST. Increased CD4+Foxp3+ T cells in BAFF-transgenic mice suppress T cell effector responses. J Immunol. 2009; 182(2):793-801.

Mariño E, Batten M, Groom J, Walters S, Liuwantara D, Mackay F, Grey ST. Marginal-zone B-cells of nonobese diabetic mice expand with diabetes onset, invade the pancreatic lymph nodes, and present autoantigen to diabetogenic T-cells. Diabetes 2008; 57:395-404.

Mariño E, Grey ST. A new role for an old player: do B cells unleash the self-reactive CD8+ T cell storm necessary for the development of type 1 diabetes? J Autoimmun. 2008; 31(3):301-5.

Liuwantara D, Elliot M, Smith MW, Yam AO, Walters SN, Marino E, McShea A, Grey ST. Nuclear factor-kappaB regulates beta-cell death: a critical role for A20 in beta-cell protection. Diabetes 2006; 55(9):2491-501.

Krauss S, Zhang CY, Scorrano L, Dalgaard LT, St-Pierre J, Grey ST, Lowell BB. Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction. J Clin Invest 2003; 112(12):1831-42.

Grey ST, Longo C, Shukri T, Patel VI, Csizmadia E, Daniel S, Arvelo MB, Tchipashvili V, Ferran C. Genetic engineering of a suboptimal islet graft with A20 preserves beta cell mass and function. J Immunol 2003; 170(12):6250-6.

Grey ST, Arvelo MB, Hasenkamp W, Bach FH, Ferran C. A20 inhibits cytokine-induced apoptosis and nuclear factor kappaB dependent gene activation in islets. J Exp Med 1999; 190(8):1135-1145.