A/Prof Marcel Dinger

Marcel Dinger is the Chief Executive Officer of Genome.One, Head of the Kinghorn Centre for Clinical Genomics (KCCG) and conjoint Associate Professor at St Vincents Clinical School of UNSW Australia. KCCG was one of the first sites in the world to implement the HiSeq X Ten genome sequencing platform
Head - Kinghorn Centre for Clinical Genomics, Lab Head - Genome Informatics

Principal Research Fellow

Conjoint/Adjunct Role(s)

Conjoint Associate Professor, St Vincent's Clinical School, Faculty of Medicine, UNSW Australia

Marcel Dinger is the Chief Executive Officer of Genome.One, Head of the Kinghorn Centre for Clinical Genomics (KCCG) and conjoint Associate Professor at St Vincents Clinical School of UNSW Australia. KCCG was one of the first sites in the world to implement the HiSeq X Ten genome sequencing platform, which has capacity to sequence 18,000 whole human genomes per year. The aims of the Centre are to establish genomic medicine in routine healthcare and to leverage clinical genomic data for research. Marcel also heads the Genome Informatics Laboratory, which is focused on understanding and dissecting the function of noncoding regions of the genome that are associated with human disease and development.

Prior to joining the Garvan Institute, Marcel headed the Cancer Transcriptomics laboratory at the Diamantina Institute at the University of Queensland. Marcel undertook his postdoctoral studies at the Institute for Molecular Bioscience where he studied the role of long noncoding RNAs in mammalian development and disease. During his postdoc, Marcel led a number of key studies demonstrating the dynamic and specific expression of long noncoding RNAs that prompted extensive functional studies of these transcripts that were commonly assumed to be “junk”.

Marcel was awarded his PhD in 2003 from the University of Waikato in New Zealand. In 2016, he was admitted as a Fellow of the Faculty of Science of the Royal Society of Pathologists of Australasia (RCPA) by Research. He is a Graduate of the Australian Institute of Company Directors and a founder of two successful IT companies.

Research Interests

The role of noncoding regions of the genome in disease
Understanding the informational architecture of the mammalian genome
Increasing the clinical utility of genome sequencing
The evolution of the tumour genome during cancer progression

In the News

Cancer test platform gains MTPConnect funding - Oct 27, 2017
Genome.One news: World-leading Australian intelligent data capture platform to aid global advancement in personalised health care - Oct 19, 2017
Leading genomic data projects to drive a new ‘world of knowledge’ - Oct 18, 2017
NHMRC funding success for Garvan - Oct 12, 2017
Garvan reaches 15,000 genomes - Jul 27, 2017
Genomics at Garvan and Genome.One highlighted on ABC - Jul 07, 2017
Genome.One news: Australia’s first whole genome and health assessment service to provide an unprecedented insight into our current and future health - Jun 20, 2017
Genomes of healthy older Australians to accelerate medical research in NSW and beyond - Dec 16, 2016
Kidney disease: whole genome sequencing holds the key to cheaper, more accurate diagnosis - Nov 04, 2016
Garvan Institute achieves major milestone: 10,000 genomes sequenced - Oct 18, 2016
New era in genetic disease diagnosis with Australia’s first whole-genome testing service to be launched today - Jul 27, 2016
Register now: Genome Gazing at Garvan - Jul 21, 2016
2016 Shine Translational Research Fellowship awarded - May 21, 2016
Landmark Lions project to provide genome sequencing to hundreds of Aussie kids with cancer - May 14, 2016
45 and Up: working with Australia’s biggest health study - Nov 18, 2015
Garvan partners with Genomics England - Sep 25, 2015
Slowing down the immune system when in overdrive - Feb 11, 2014
The future of genomic medicine has arrived in Australia - Jan 15, 2014

Awards and Honours

2016 - Fellow of the Faculty of Science (Research), Royal Society of Pathologists of Australasia
2012 - Theo Murphy Think Tank Participant
2010 - NHMRC Career Development Award Level 1
2010 - AMATA Best Oral Presentation
2009 - Queensland Government Smart Futures Fellowship
2008 - Fresh Scientist
2005 - Foundation of Research, Science and Technology New Zealand Postdoctoral Fellowship
1999 - University of Waikato PhD Scholarship
1997 - University of Waikato Masters and Honours Awards

Education

2016 - Graduate of the Australian Institute of Company Directors
2003 - PhD, Biochemistry, University of Waikato - New Zealand
1998 - MSc (Hons I), Biochemistry, University of Waikato - New Zealand
1996 - BSc, Biochemistry & Genetics, University of Waikato - New Zealand

Selected Publications

Signal B, Gloss BS, Dinger ME. Computational Approaches for Functional Prediction and Characterisation of Long Noncoding RNAs. Trends in Genetics 32:620-37.

Thomson DW, Dinger ME (2016). Endogenous microRNA sponges: evidence and controversy. Nature Reviews Genetics 17: 272–283.

Clark MB, Mercer TR, Bussotti G, Leonardi T, Haynes KR, Crawford J, Brunck ME, Cao KA, Thomas GP, Chen WY, Taft RJ, Nielsen LK, Enright AJ, Mattick JS, Dinger ME (2015). Quantitative gene profiling of long noncoding RNAs with targeted RNA sequencing. Nature Methods 12:339-42. 

Gloss BS, Dinger ME (2015). The specificity of long noncoding RNA expression. Biochim Biophys Acta 1859:16-22.

Quek XC, Thomson DW, Maag JL, Bartonicek N, Signal B, Clark MB, Gloss BS, Dinger ME (2015). lncRNAdb v2.0: expanding the reference database for functional long noncoding RNAs. Nucleic Acids Research 2015; 43:D168-73. 

Mattick JS, Dinger ME (2013). The extent of functionality in the human genome. HUGO Journal 7: 2.

Cheetham S, Gruhl F, Mattick JS, Dinger ME (2013). Long noncoding RNAs and the genetics of cancer. British Journal of Cancer 108:2419-25.

Clark MB, Johnston RL, Inostroza-Ponta M, Fox AH, Fortini E, Moscato P, Dinger ME*, Mattick JS* (2012). Genome-wide analysis of long noncoding RNA stability. Genome Research 22:885-898.

Mercer TR, Gerhardt DJ, Dinger ME, Crawford J, Trapnell C, Jeddeloh JA, Mattick JS, Rinn, JL (2012). Targeted RNA sequencing reveals the deep complexity of the human transcriptome. Nature Biotecnnology 30:99-104.

Khaitan D*, Dinger ME*, Mazar J, Crawford J, Smith MA, Mattick JS, Perera RJ (2011). The melanoma-upregulated long noncoding RNA SPRY4-IT1 modulates apoptosis and invasion. Cancer Research 71:3852-3862.

Mercer TR*, Dinger ME*, Mattick JS (2009). Long noncoding RNAs: insights into function. Nature Reviews Genetics 10:155-159.

Dinger ME, Amaral PP, Mercer TR, Pang KC, Bruce SJ, Gardiner BB, Askarian-Amiri ME, Ru K, Soldà G, Simons C, Sunkin SM, Crowe ML, Grimmond SM, Perkins AC, Mattick JS (2008). Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation. Genome Research 18:1433-1445.

Mercer TR*, Dinger ME*, Sunkin SM, Mehler MF, Mattick JS (2008). Specific expression of long noncoding RNAs in the adult mouse brain. Proc Natl Acad Sci USA 105:716-721.

Amaral PP, Dinger ME, Mercer TR, Mattick JS (2008). The eukaryotic genome as an RNA machine. Science 319:1787-1789.

Person portrait

A/Prof Marcel Dinger



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