The Kinghorn Centre for Clinical Genomics (KCCG) is led by Associate Professor Marcel Dinger and comprises six program teams that work closely together.
Since 2012, KCCG grew to more than 60 team members with skills across sequencing, informatics, clinical interpretation, business development, and education. In 2016, Garvan launched its wholly-owned subsidiary, Genome.One to provide genetic answers to health questions through clinical whole genome sequencing and analysis. In 2017, with continued support from the Kinghorn Foundation, KCCG reorganised into six key teams that tackle major challenges that will ultimately enable advance the translation of genomic information to improve health.
The programs are:
- Translational Genome Informatics
- Genomic Technologies
- Tumour Genomics
- Education and Communication
The Centre Management team is responsible for the broad oversight of KCCG operations and its interaction with with Genome.One. This includes: the management of flagship-sequencing projects initiated through the Sydney Genomics Collaborative; the management and promotion of KCCG sequencing services to both the national and international research community; the development and maintenance of new and on going collaborations and partnerships; and the procurement of external funding for genomic research and infrastructure.
|A/Prof Marcel Dinger||Dr Marie-Jo Brion||Melissa Vincent|
Translational Genome Informatics
To expand the clinical utility of whole-genome sequencing by developing algorithms to annotate pathogenic loci in noncoding regions of the genome, applied to a range of rare monogenic disorders of substantial unmet need.
The KCCG Genomic Technologies program aims to ensure that the Garvan Institute is at the cutting edge of the rapidly evolving genomics technology landscape by evaluating new sequencing platforms, developing new methodologies, and translating these applications into clinical and commercial settings.
The KCCG Phenomics program aims to provide comprehensive solutions to enrich the understanding of the associations occurring between diseases, genotype, phenotype and environment via structured knowledge representation and discovery techniques.
The KCCG Informatics Program aims to organize the world’s genome information and make it universally accessible and useful to authorised users.
The KCCG Tumour Genomics Program aims to establish a rapid and cost-effective genomics tests for cancer diagnosis, prognosis, and risk prediction, which include whole-genome somatic cancer testing, focussed capture sequencing, and inherited cancer predisposition screening.
Education and Communication
The KCCG Education and Communication Program aims to develop and deliver targeted educational programs and resources for health professionals and diverse communities on the complex and fast-moving field of genomics.
The impact of clinical genomics is becoming widespread and its importance to diverse disciplines is becoming increasingly recognised. KCCG engages closely with scientists, clinicians and ethicists through visiting appointments. These individuals bring additional expertise to KCCG and provide a mechanism for reciprocal engagement into the broader genomics community.
|Prof Andreas Zankl||Dr Jacqueline Savard||Dr Paul Lacaze||
|Dr Elizabeth (Emma) Palmer||Prof Carolyn Sue||Dr Ryan Davis||Peter Priestley|