HiSeq X Ten

In 2014, the Kinghorn Centre for Clinical Genomics acquired and installed an Illumina’s HiSeq X Ten system.

(c) Illumina

The HiSeq X Ten is the world’s first sequencing platform to break the USD 1,000 barrier for 30x coverage of a human genome. When used 
at scale, the HiSeq X Ten delivers a USD 1,000 genome, inclusive of instrument depreciation, sequencing consumables, DNA extraction, library preparation, and estimated labour for a typical high-throughput genomics laboratory.

The HiSeq X Ten platform comprises ten HiSeq X sequencing instruments. Each instrument is capable of generating up to 1.8 terabases of data every 3 days, which is sufficient to sequence a 16 whole human genomes at 30x coverage. Combined, the HiSeq X Ten platform has capacity to sequence 350 genomes per week or 18,000 genomes per year.

This tremendous advance in both volume and cost of whole genome sequencing provides a practical avenue for the clinical translation of genomic medicine. KCCG has made publicly available sample data from the reference genome NA12878.

Further information regarding the release of the HiSeq X Ten is detailed in the following press releases:

The future of genomic medicine has arrived in Australia (Garvan Institute)

Illumina Introduces the HiSeq X™ Ten Sequencing System (Illumina).


Header image credit and copyright: Illumina (www.illumina.com)