Teams

A/Prof Marcel Dinger

KCCG Team Structure

The Kinghorn Centre for Clinical Genomics (KCCG) is led by Associate Professor Marcel Dinger and comprises five teams that work closely together.

Since 2012, KCCG grew to more than 60 team members with skills across sequencing, informatics, clinical interpretation, business development, and education. In 2016, Garvan launched its wholly-owned subsidiary, Genome.One to provide genetic answers to health questions through clinical whole genome sequencing and analysis. In 2017, with continued support from the Kinghorn Foundation, KCCG reorganised into five key teams that tackle major challenges that will ultimately enable advance the translation of genomic information to improve health:

 

The teams are:    
Translational Genome Informatics Genomic Technologies Population-scale Health Analytics
Cancer Genomics Education and Engagement Visiting Scientists

  

Centre management

The Centre Management team is responsible for the broad oversight of KCCG operations and its interaction with with Genome.One. This includes: the management of flagship-sequencing projects initiated through the Sydney Genomics Collaborative; the management and promotion of KCCG sequencing services to both the national and international research community; the development and maintenance of new and on going collaborations and partnerships; and the procurement of external funding for genomic research and infrastructure. 

 

marbri.jpg Mel Vincent
A/Prof Marcel Dinger Dr Marie-Jo Brion Melissa Vincent

 

Translational Genome Informatics

This team has been brought together to advance the state-of-the-art in whole genome interpretation for the clinic. The team develops new tools and algorithms for reliably identifying and classifying noncoding regions of the genome that could directly relate to disease pathogenicity, with the aim of expanding the scope of clinical reporting. This team aims to advance the field of whole genome interpretation and enable translation of this research to Genome.One, so that it has access to the most advanced approaches in clinical interpretation.

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Dr Alexander Drew Dr Kishore Kumar Dr Andre Minoche Clare Puttick
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Dr Nenad Bartonicek Dr Lisa Ewans James Torpy Mahdi Zeraati
Garry Chadbond  Amali  Beth-Signal-IMG_0420.JPG briglo.jpg
Dr Madhura Bakshi Dr Amali Mallawaarachchi Beth Signal  Dr Brian Gloss

 

Genomic Technologies

This team is responsible for evaluating new genomics technologies for both clinical and research applications and, where appropriate, establish a pathway for translation of new technologies and techniques into Genome.One.

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Dr Martin Smith James Ferguson

 

Population-scale Health Analytics

This team, led by Dr Tudor Groza and Dr Warren Kaplan focuses on devising computational approaches to infer actionable knowledge from large-scale genotype – phenotype associations. Particular topics will include population statistical genomics, text/data mining and Machine Learning from EHRs, building temporal disease models from the genome – phenome – exposome triumvirate. The aim is to provide an analytical framework to cover the diagnosis – prevention continuum for improved clinical and patient care.

 

Tudor Warren dmideg-2.jpg Shane Husson
Dr Tudor Groza Dr Warren Kaplan Dmitry Degrave Shane Husson
Simon Kocbek Derrick Lin Dr Frank Lin Manuel Sopena-Ballesteros
Dr Simon Kocbek Derrick Lin Dr Frank Lin Manuel Sopena-Ballesteros

  

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Cancer Genomics

 The KCCG Cancer Genomics team develops approaches to analyse and interpret cancer genome data, predominantly for patients with rare and advanced cancers. The team has a strong focus on translational research, and as such develops approaches to enable fast, accurate analysis and interpretation of individual tumour genomes. The team works closely with the Garvan Genomic Cancer Medicine program and leads the genomic analyses of the Molecular Stratified Therapeutics Trial (MoST), and the Lions Kids Cancer Genome Project (LKCGP). This is complemented by research focussed on tumour evolution, noninvasive monitoring, and understanding the drivers of rare cancers.

Mark Cowley Mark McCabe marwo2.jpg.jpeg Vel
Dr Mark Cowley Dr Mark McCabe Dr Marie Wong Dr Velimir Gayevskiy
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Dr John Grady Dr Nisa Sheriff Chia-Ling Chan  

 

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Education and Engagement

Our education and communication program, led by Bronwyn Terrill, focuses on engaging health care professionals and the diverse communities that make up our population with the complex and fast-moving field of genomics.

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Bronwyn Terrill Krista Recsei Andrew Gibb Ben Hall


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Visiting Scientists

The impact of clinical genomics is becoming widespread and its importance to diverse disciplines is becoming increasingly recognised. KCCG engages closely with scientists, clinicians and ethicists through visiting appointments. These individuals bring additional expertise to KCCG and provide a mechanism for reciprocal engagement into the broader genomics community.

Andreas Dr Jacqueline Savard Julia Yin
Prof Andreas Zankl Dr Jacqueline Savard Dr Paul Lacaze

Julia Yin

elipal.jpg.jpeg Garry Chadbond Garry Chadbond Garry Chadbond
Dr Elizabeth (Emma) Palmer  Prof Carolyn Sue Dr Ryan Davis  Peter Priestley 

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