Genome sequencing

Discovery @ Genome.One

Institutional Member

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A/Prof Marcel Dinger

KCCG Team Structure

The Kinghorn Centre for Clinical Genomics (KCCG) is led by Associate Professor Marcel Dinger and comprises five programs that work closely together.

Since 2012, KCCG grew to more than 60 team members with skills across sequencing, informatics, clinical interpretation, business development, and education. In 2016, Garvan launched its wholly-owned subsidiary, Genome.One to provide genetic answers to health questions through clinical whole genome sequencing and analysis. Since that time, KCCG has started to reorganise into five new research programs and a management team:


Centre management Clinical genome informatics Genomic technologies
Cancer Genomics Population-scale Health Analytics Education and Engagement

Visiting Scientists



Centre management

The Centre management team is responsible for the broad oversight of KCCG operations. This includes: the management of flagship-sequencing projects initiated through the Sydney Genomics Collaborative; the management and promotion of KCCG sequencing services to both the national and international research community; the development and maintenance of new and on going collaborations and partnerships; and the procurement of external funding for genomic research and infrastructure.

marbri.jpg Mel Vincent
Dr Andrew Stone Dr Marie-Jo Brion Melissa Vincent


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Clinical genome informatics

This team has been brought together to advance the state-of-the-art in whole genome interpretation for the clinic. It will develop new tools and algorithms for reliably identifying and classifying noncoding regions of the genome that could directly relate to disease pathogenicity, with the aim of expanding the scope of clinical reporting. This team would advance the field of whole genome interpretation and enable translation of this research to Genome.One, so that it has access to the most advanced approaches in clinical interpretation.

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Alexander Drew Dr Andre Minoche Nenad Bartonicek Clare Puttick
kishore kumar Lisa Ewans profile mahzer.jpg
Dr Kishore Kumar Dr Lisa Ewans Dr Amali Mallawaarachchi Mahdi Zeraati
Madhura Bakshi Beth Signal James Torpy  


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Genomic technologies

This team will be responsible for evaluating new genomics technologies for both for clinical and research applications and, where appropriate, establish a pathway for translation of new technologies and techniques into Genome.One.

Martin Smith James Ferguson    

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Cancer Genomics

This group will research and develop clinically robust methods and pipelines to enable a scalable and economic approach to sequencing and analyzing cancer genomes and returning clinically valuable reports. This group will work closely with the Genomic Technologies group to develop state of the art cancer tests.

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Dr Mark Cowley Dr Mark McCabe Marie Wong Brian Gloss
John Grady Dr Velimir Gayevskiy Nissa Sheriff  

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Population-scale Health Analytics

This team, led by Dr Tudor Groza and Dr Warren Kaplan will focus on devising computational approaches to infer actionable knowledge from large-scale genotype – phenotype associations. Particular topics will include population statistical genomics, text/data mining and Machine Learning from EHRs, building temporal disease models from the genome – phenome – exposome triumvirate. The aim is to provide an analytical framework to cover the diagnosis – prevention continuum for improved clinical and patient care.

Tudor Warren Dmitry Degrave
Dr Tudor Groza Dr Warren Kaplan Dmitry Degrave Shane Husson
Simon Kocbek Derrick Lin Dr Frank Lin Manuel Sopena-Ballesteros
Dr Simon Kocbek Derrick Lin Dr Frank Lin

Manuel Sopena-Ballesteros

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Education and Engagement

Our education and engagement program, led by Bronwyn Terrill, focuses on engaging health care professionals and the diverse communities that make up our population with the complex and fast-moving field of genomics.

Bronwyn Terrill Krista Recsei andgib.jpg  
Bronwyn Terrill Krista Recsei Andrew Gibb Ben Hall  

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Visiting Scientists

The impact of clinical genomics is becoming widespread and its importance to diverse disciplines is becoming increasingly recognised. KCCG engages closely with scientists, clinicians and ethicists through visiting appointments. These individuals bring additional expertise to KCCG and provide a mechanism for reciprocal engagement into the broader genomics community.

Andreas Dr Jacqueline Savard Julia Yin
Prof Andreas Zankl Dr Jacqueline Savard Dr Paul Lacaze

Julia Yin

Dr Elizabeth Palmer      

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