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3D Epigenome in Cancer Group

The focus of the group is to understand how the three-dimensional (3D) organisation of DNA inside the nucleus relates to gene deregulation in cancer, including its cell-to-cell and temporal variability.

Central to this is understanding the role of epigenome and 3D genome alterations in driving cancer development, progression and treatment resistance, with a focus on breast and prostate cancer. For that, we combine and integrate cutting-edge genomics technology, single-cell epigenome profiling, genome editing and pre-clinical models to study the interplay of the 3D genome and epigenome in cancer.

The group has key interest in developing new epigenomic and single-cell technologies, including ongoing optimisation of chromosome conformation capture-based methods (Hi-C, Capture Hi-C, HiChIP) and bioinformatics for 3D genome structure mapping and the development of high-throughput single-cell and spatial 3D genome and epigenome profiling techniques.

Research team

Selected publications

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