Developmental and Disease Epigenomics Group
Understanding the development of the immune system and the pathogenesis of female-biased autoimmunity.
The group’s main research goal is to elucidate the the evolution of epigenetic mechanisms controlling allelic exclusion, X chromosome inactivation and autosomal imprinting; and their roles in the development of the immune system and the pathogenesis of female-biased autoimmunity.
To achieve this goal, we employ and integrate cutting-edge single-cell transcriptomics and epigenomics technologies, flow cytometry, immunohistochemistry, chromatin modifications profiling of immune cells from animal models and clinical samples, CRISPR genome editing, as well as multi-omics bioinformatic analysis.
Our research program aims to advance knowledge in the intersection of epigenetics, B cell biology and RNA biology, that are critical to understanding autoimmunity. The results will provide an extensive resource and further the understanding of female-specific epigenetic regulation of normal B cell development and pathogenesis of autoimmunity, addressing significant unanswered questions in immunology and epigenetics.
In addition to fundamental discoveries, the group aims to provide rationale for the improvement of autoimmune disease biomarkers by combing newly discovered epigenetic alterations with autoantibody tests and genetic mutations.
- 2022Science advances10.1126/sciadv.abn2258
Active DNA demethylation of developmental -regulatory regions predates vertebrate origins.
- 2019Cancer cell10.1016/j.ccell.2019.01.004
DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns.
- 2019Nature communications10.1038/s41467-019-10895-6
Retention of paternal DNA methylome in the developing zebrafish germline.
- 2018Nature reviews. Molecular cell biology10.1038/s41580-018-0074-2
Functions and mechanisms of epigenetic inheritance in animals.
- 2017Epigenetics & chromatin10.1186/s13072-017-0123-7
Comprehensive evaluation of genome-wide 5-hydroxymethylcytosine profiling approaches in human DNA.