Antibody Therapeutics Lab

Publications

Systematic functional identification of cancer multi-drug resistance genes
Lau MT., Ghazanfar S., Parkin A., Chou A., Rouaen JR., Littleboy JB., Nessem D., Khuong TM., Nevoltris D., Schofield P., Langley D., Christ D., Yang J., Pajic M., Neely GG.
GENOME BIOLOGY 21(1):27, 2020
Repertoires of aggregation-resistant human antibody domains
Christ, D.;Famm, K.;Winter, G. :
PROTEIN ENGINEERING DESIGN & SELECTION 20(8):413-6, 2007
A Novel Mutation in Nucleoporin 35 Causes Murine Degenerative Colonic Smooth Muscle Myopathy
Parish, I. A.; Stamp, L. A.; Lorenzo, A. M.; Fowler, S. M.; Sontani, Y.; Miosge, L. A.; Howard, D. R.; Goodnow, C. C.; Young, H. M.; Furness, J. B.;
AMERICAN JOURNAL OF PATHOLOGY 186(9):2254-61, 2016
Thinking small: challenges and opportunities for non-antibody scaffold drugs
Vazquez-Lombardi, R.; Phan, T. G.; Zimmermann, C.; Lowe, D.; Jermutus, L.; Christ, D.
DRUG DISCOVERY TODAY 10(1016):1271-83, 2015
Expression of IgG Monoclonals with Engineered Immune Effector Functions
Vazquez-Lombardi, R.; Nevoltris, D.; Rouet, R.; Christ, D.
Methods in Molecular Biology 1827:313-334, 2018
Selection of Antibody Fragments Against Structured DNA by Phage Display
Zeraati, M.; Dinger, M. E.; Christ, D.
Methods in Molecular Biology 1827:197-209, 2018
Selection of human antibody fragments by phage display
Lee, C. M.;Iorno, N.;Sierro, F.;Christ, D. :
Nature Protocols 2(11):3001-8, 2007
Solution structure of a soluble fragment derived from a membrane protein by shotgun proteolysis.
Allen, M. D.; Christie, M.; Jones, P.; Porebski, B. T.; Roome, B.; Freund, S. M.; Buckle, A. M.; Bycroft, M.; Christ, D.;
PROTEIN ENGINEERING DESIGN & SELECTION 28(10):445-50, 2015
Expression of Human VH Single Domains as Fc Fusions in Mammalian Cells
Abdelatti, M.; Schofield, P.; Christ, D.
Methods in Molecular Biology 1953:121-136, 2019
Selection of human VH single domains with improved biophysical properties by phage display
Dudgeon, K.; Rouet, R.; Famm, K.; Christ, D.;
Methods in Molecular Biology 911:383-97, 2012
PDGFRalpha Drives Pulmonary Vascular Progenitor Cells Recruitment, Vascular Remodeling and Pulmonary Hypertension Development
Julien Solinc , Jessica Raimbault-Machado , France Dierick , Lamiaa El Bernoussi , Bénédicte Hoareau-Coudert , Virginie Monceau , Fabrice Atassi , Giovanna Marazzi , David A Sassoon , Richard Harvey , Daniel Christ , Peter Schofield , Catherine Pavoine , Florent Soubrier , Sophie Nadaud
CIRCULATION 140(1) 2019
Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens
Burnett, D. L.; Schofield, P.; Langley, D. B.; Jackson, J.; Bourne, K.; Wilson, E.; Porebski, B. T.; Buckle, A. M.; Brink, R.; Goodnow, C. C.; Christ, D.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 117(36):22341-22350, 2020
Redemption of autoantibodies on anergic B cells by V-region glycosylation and mutation away from self-reactivity
Sabouri Z, Schofield PR, Horikawa K, Spierings E, Kipling E, Randall K, Langley D, Roome B, Vazquez-Lombardi R, Rouet R, Hermes J, Chan T, Brink R, Dunn-Walters DK, Christ D and Goodnow CC
P NATL ACAD SCI USA 2014
Structural basis of antigen recognition: crystal structure of duck egg lysozyme
Langley, D. B.; Crossett, B.; Schofield, P.; Jackson, J.; Zeraati, M.; Maltby, D.; Christie, M.; Burnett, D.; Brink, R.; Goodnow, C.; Christ, D.
Acta Crystallographica Section D-Structural Biology 73(Pt 11):910-920, 2017
Structural reconstruction of protein ancestry
Rouet, R.; Langley, DB.; Schofield,P.; Christie, M.; Roome, B.; Porebski, BT.; Buckle,AM.; Clifton, BE.; Jackson, CJ.; Stock, D.; Christ, D.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 114(5):3897-3902, 2017
Transient expression of human antibodies in mammalian cells
Vazquez-Lombardi, R.; Nevoltris, D.; Luthra, A.; Schofield, P.; Zimmermann, C.; Christ, D.
Nature Protocols 13(1):99-117, 2018
SARS-CoV-2 neutralizing antibodies: Longevity, breadth, and evasion by emerging viral variants
F. Tea, A. Ospina Stella, A. Aggarwal, D. Darley, D. Pilli, D. Vitale, V. Merheb, F. X. Lee, P. Cunningham, G. Walker, D. A. Brown, W. Rawlinson, S. Isaacs, V. Mathivanan, M. Hoffman, S. Poehlmann, D. Dwyer, R. Rockett, V. Sintchenko, V. Hoad, D. Irving, G. Dore, I. Gosbell, A. Kelleher, G. Matthews, F. Brilot, S. Turville
PLOS MEDICINE 18(7)::e1003656, 2021
Structure of GUN4 from Chlamydomonas reinhardtii
Tarahi Tabrizi, S.
; Langley, D. B.
; Harrop, S. J.
; Duff, A. P.
; Willows, R. D.;
Acta Crystallogr F Struct Biol Commun 71(Pt 8):1094-9, 2015
Structure and characterisation of a key epitope in the conserved C-terminal domain of the malaria vaccine candidate MSP2
Seow, J.; Morales, R.; MacRaild, CA.; Krishnarjuna, B.; McGowan, S.; Dingjan, T.; Jaipuria, G.; Rouet,R.; Wilde, KL.; Atreya, HS.; Richards, JS.; Anders, RF.; Christ, D.; Drinkwater, N.; Norton, RS.
JOURNAL OF MOLECULAR BIOLOGY 429(6):836-846, 2017
DNA G-Quadruplex and i-Motif Structure Formation Is Interdependent in Human Cells
King, J. J.; Irving, K. L.; Evans, C. W.; Chikhale, R. V.; Becker, R.; Morris, C. J.; Pena Martinez, C. D.; Schofield, P.; Christ, D.; Hurley, L. H.; Waller, Z. A. E.; Iyer, K. S.; Smith, N. M.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 142(49):20600-20604, 2020
GDF15 mediates adiposity resistance through actions on GFRAL neurons in the hindbrain AP/NTS
Tsai, V. W.; Zhang, H. P.; Manandhar, R.; Schofield, P.; Christ, D.; Lee-Ng, K. K. M.; Lebhar, H.; Marquis, C. P.; Husaini, Y.; Brown, D. A.; Breit, S. N.
INTERNATIONAL JOURNAL OF OBESITY 43(12):2370-2380, 2019
Long-term persistence of RBD(+) memory B cells encoding neutralizing antibodies in SARS-CoV-2 infection
Abayasingam, A.; Balachandran, H.; Agapiou, D.; Hammoud, M.; Rodrigo, C.; Keoshkerian, E.; Li, H.; Brasher, N. A.; Christ, D.; Rouet, R.; Burnet, D.; Grubor-Bauk, B.; Rawlinson, W.; Turville, S.; Aggarwal, A.; Stella, A. O.; Fichter, C.; Brilot, F.; Mina, M.; Post, J. J.; Hudson, B.; Gilroy, N.; Dwyer, D.; Sasson, S. C.; Tea, F.; Pilli, D.; Kelleher, A.; Tedla, N.; Lloyd, A. R.; Martinello, M.; Bull, R. A.; Cosin Study Group
Cell Reports 2(4):100228, 2021
Protein A superantigen: structure, engineering and molecular basis of antibody recognition
Mazigi, O.; Schofield, P.; Langley, D. B.; Christ, D.
Protein Eng 32(8):359-366, 2019
Mapping the extent of heterogeneity of human CCR5+ CD4+ T cells in peripheral blood and lymph nodes
Zaunders, J.; Munier, C. M. L.; McGuire, H. M.; Law, H.; Howe, A.; Xu, Y.; de St Groth, B. F.; Schofield, P.; Christ, D.; Milner, B.; Obeid, S.; Dyer, W. B.; Saksena, N. K.; Kelleher, A. D.
AIDS 34(6):833-848, 2020
Potent antitumour activity of IL-2-Fc fusion proteins requires Fc-mediated depletion of regulatory T-cells
Vazquez-Lombardi,R; Loetsch, C; Zinkl,D; Jackson,J; Schofield, P; Deenick, EK; King,C; Phan, T; Webster, KE; Sprent, J; Christ,C
Nature Communications 8:15373, 2017
Reproducibility: Standardize antibodies used in research.
Bradbury, A; Christ, D.
NATURE 518(7537) 2015
Crystal structure of duck egg lysozyme isoform II (DEL-II)
Langley, D. B.; Christ, D.
BMC STRUCTURAL BIOLOGY 18(1):10, 2018
Interleukin-21 and interleukin-4 collaborate to shape T dependent antibody responses
McGuire, HM; Vogelzang, A; Warren, J; Loetsch, C; Natividad, KD; Chan, TD; Brink, R; Marcel, B; King, C.
JOURNAL OF IMMUNOLOGY 10(4049):5123-25, 2015
Generation of human single domain antibody repertoires by kunkel mutagenesis
Rouet, R.; Dudgeon, K.; Christ, D.;
Methods in Molecular Biology 907:195-209, 2012
Surface-associated antigen induces permeabilization of primary mouse B-cells and lysosome exocytosis facilitating antigen uptake and presentation to T-cells
Maeda, F. Y.; van Haaren, J. J.; Langley, D. B.; Christ, D.; Andrews, N. W.; Song, W.
eLife 10:e66984, 2021
Human Antibody Bispecifics through Phage Display Selection
Luthra, A.; Langley, D. B.; Schofield, P.; Jackson, J.; Abdelatti, M.; Rouet, R.; Nevoltris, D.; Mazigi, O.; Crossett, B.; Christie, M.; Christ, D.
Biochemistry 58(13):1701-1704, 2019
Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies
Rouet, R.; Mazigi, O.; Walker, G. J.; Langley, D. B.; Sobti, M.; Schofield, P.; Lenthall, H.; Jackson, J.; Ubiparipovic, S.; Henry, J. Y.; Abayasingam, A.; Burnett, D.; Kelleher, A.; Brink, R.; Bull, R. A.; Turville, S.; Stewart, A. G.; Goodnow, C. C.; Rawlinson, W. D.; Christ, D.
mAbs 13(1):1922134, 2021