Bone Microenvironment

Inhibition of sclerostin systemic treatment with sclerostin antibody enhances healing of proximal tibial defects in ovariectomized rats.

McDonald, M.M.; Morse, A.; Mikulec, K.; Peacock, L.; Yu, N.; Baldock, P.A.; Birke, O.; Liu, M.; Ke, H.Z.; Little, D.G.

JOURNAL OF ORTHOPAEDIC RESEARCH 30(10):1541-8, 2012

Sclerostin antibody enhances bone formation in a rat model of distraction osteogenesis

McDonald, M. M.; Morse, A.; Birke, O.; Yu, N. Y. C.; Mikulec, K.; Peacock, L.; Schindeler, A.; Liu, M.; Ke, H. Z.; Little, D. G.

JOURNAL OF ORTHOPAEDIC RESEARCH 36(4):1106-1113, 2018

Increased anabolic bone response in Dkk1 KO mice following tibial compressive loading

Morse, A.; Ko, F.; McDonald, M. M.; Lee, L.; Schindeler, A.; van der Meulen, M. C. H.; Little, D. G.

BONE 131:115054, 2020

Sclerostin: an Emerging Target for the Treatment of Cancer-Induced Bone Disease

McDonald, M. M.; Delgado-Calle, J.

Current Osteoporosis Reports 15(6):532-541, 2017

Sclerostin Antibody Augments the Anabolic Bone Formation Response in a Mouse Model of Mechanical Tibial Loading

Morse, A.; Schindeler, A.; McDonald, M. M.; Kneissel, M.; Kramer, I.; Little, D. G.

JOURNAL OF BONE AND MINERAL RESEARCH 33(3):486-498, 2018

Sclerostin antibody increases callus size and strength but does not improve fracture union in a challenged open rat fracture model

Morse, A.; McDonald, M. M.; Schindeler, A.; Peacock, L.; Mikulec, K.; Cheng, T. L.; Liu, M.; Ke, H. Z.; Little, D. G.

CALCIFIED TISSUE INTERNATIONAL 101(2):217-228, 2017

Tumor Cell Dormancy—a Hallmark of Metastatic Growth and Disease Recurrence in Bone

Haydar, N.; McDonald, M.M.

Current Molecular Biology Reports 4(2):50-58, 2018

Dkk1 KO Mice Treated with Sclerostin Antibody Have Additional Increases in Bone Volume

Morse, A.; Cheng, T. L.; Schindeler, A.; McDonald, M. M.; Mohanty, S. T.; Kneissel, M.; Kramer, I.; Little, D. G.

CALCIFIED TISSUE INTERNATIONAL 103(3):298-310, 2018

Adipose, Bone, and Myeloma: Contributions from the Microenvironment

McDonald, M. M.; Fairfield, H.; Falank, C.; Reagan, M. R.

CALCIFIED TISSUE INTERNATIONAL 100(5):433-448, 2017

Tumor cell dormancy and reactivation in bone: skeletal biology and therapeutic opportunities

Byrne, N.M., Summers, M.A. and McDonald, M.M.

JOURNAL OF BONE AND MINERAL RESEARCH PLUS 3(3):e10125, 2019

Elevated Bone Hardness Under Denosumab Treatment, With Persisting Lower Osteocyte Viability During Discontinuation

Jahn-Rickert, K.; Wolfel, E. M.; Jobke, B.; Riedel, C.; Hellmich, M.; Werner, M.; McDonald, M. M.; Busse, B.

Frontiers in Endocrinology 11:250, 2020

Homozygous Dkk1 Knockout Mice Exhibit High Bone Mass Phenotype Due to Increased Bone Formation

McDonald, M. M.; Morse, A.; Schindeler, A.; Mikulec, K.; Peacock, L.; Cheng, T.; Bobyn, J.; Lee, L.; Baldock, P. A.; Croucher, P. I.; Tam, P. P. L.; Little, D. G.

CALCIFIED TISSUE INTERNATIONAL 102(1):105-116, 2018

Iodinated contrast does not alter clotting dynamics in acute ischemic stroke as measured by thromboelastography

McDonald, M. M.; Archeval-Lao, J. M.; Cai, C.; Peng, H.; Sangha, N.; Parker, S. A.; Wetzel, J.; Riney, S. A.; Cherches, M. F.; Guthrie, G. J.; Roper, T. C.; Kawano-Castillo, J. F.; Pandurengan, R.; Rahbar, M. H.; Grotta, J. C.;

STROKE 45(2):462-6, 2014

New Insights Into Osteoclast Biology

McDonald, M. M.; Kim, A. S.; Mulholland, B. S.; Rauner, M.

JOURNAL OF BONE AND MINERAL RESEARCH PLUS 5(9):e10539, 2021

The skeletal cell-derived molecule sclerostin drives bone marrow adipogenesis

Fairfield H, Falank C, Harris E, Demambro V, McDonald M, Pettitt JA, Mohanty ST, Croucher P, Kramer I, Kneissel M, Rosen CJ, Reagan MR.

JOURNAL OF CELLULAR PHYSIOLOGY 233(2):1156-1167, 2018

Pretreatment with Pamidronate Decreases Bone Formation but Increases Callus Bone Volume in a Rat Closed Fracture Model

Morse, A.; McDonald, M. M.; Mikulec, K.; Schindeler, A.; Munns, C. F.; Little, D. G.

CALCIFIED TISSUE INTERNATIONAL 106(2):172-179, 2020