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Bone Therapeutics Lab

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A highly sensitive prenylation assay reveals in vivo effects of bisphosphonate drug on the Rab prenylome of macrophages outside the skeleton
Ali, N.
; Jurczyluk, J.
; Shay, G.
; Tnimov, Z.
; Alexandrov, K.
; Munoz, M. A.
; Skinner, O. P.
; Pavlos, N. J.
; Rogers, M. J.;
Small GTPases 30(4):637-46, 2015
Defective Protein Prenylation in a Spectrum of Patients With Mevalonate Kinase Deficiency
Munoz, M. A.; Jurczyluk, J.; Simon, A.; Hissaria, P.; Arts, R. J. W.; Coman, D.; Boros, C.; Mehr, S.; Rogers, M. J.
Frontiers in Immunology 10:1900, 2019
From vesicle to cytosol
Rogers, M. J.; Munoz, M. A.
eLife 7:e38847, 2018
Oxysterols: From physiological tuners to pharmacological opportunities
Brown, A. J.; Sharpe, L. J.; Rogers, M. J.
BRITISH JOURNAL OF PHARMACOLOGY 178(16):3089-3103, 2021
Lack of protein prenylation promotes NLRP3 inflammasome assembly in human monocytes
Skinner, O. P.; Jurczyluk, J.; Baker, P. J.; Masters, S. L.; Rios Wilks, A. G.; Clearwater, M. S.; Robertson, A. A. B.; Schroder, K.; Mehr, S.; Munoz, M. A.; Rogers, M. J.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 143(6):2315-2317 e3, 2019
Defective protein prenylation is a diagnostic biomarker of mevalonate kinase deficiency
Munoz, M. A.; Jurczyluk, J.; Mehr, S.; Chai, R. C.; Arts, R. J. W.; Sheu, A.; McMahon, C.; Center, J. R.; Singh-Grewal, D.; Chaitow, J.; Campbell, D. E.; Quinn, J. M. W.; Alexandrov, K.; Tnimov, Z.; Tangye, S. G.; Simon, A.; Phan, T. G.; Rogers, M. J.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 140(3):873-875.e6, 2017
Bisphosphonate drugs have actions in the lung and inhibit the mevalonate pathway in alveolar macrophages
Munoz, M. A.; Fletcher, E. K.; Skinner, O. P.; Jurczyluk, J.; Kristianto, E.; Hodson, M. P.; Sun, S.; Ebetino, F. H.; Croucher, D. R.; Hansbro, P. M.; Center, J. R.; Rogers, M. J.
eLife 10:e72430, 2021
Oxysterols: From Physiological Tuners to Pharmacological Opportunities
Brown, A. J.; Sharpe, L. J.; Rogers, M. J.
BRITISH JOURNAL OF PHARMACOLOGY 2020
Synthesis and Characterization of Bone Binding Antibiotic-1 (BBA-1), a Novel Antimicrobial for Orthopedic Applications
Kamble, S.; Valtchev, P.; Dao, A.; Pelras, T.; Rogers, M. J.; Savage, P. B.; Dehghani, F.; Schindeler, A.
MOLECULES 26(6) 2021
Molecular mechanisms of action of bisphosphonates and new insights into their effects outside the skeleton
Rogers, M. J.; Monkkonen, J.; Munoz, M. A.
BONE 139:115493, 2020