Cancer Developmental Biology Lab


MCAM mediates chemoresistance in small cell lung cancer via the PI3K/AKT/SOX2 signaling pathway
Tripathi, S. C.; Fahrmann, J. F.; Celiktas, M.; Aguilar, M.; Marini, K. D.; Jolly, M. K.; Katayama, H.; Wang, H.; Murage, E. N.; Dennison, J. B.; Watkins, D. N.; Levine, H.; Ostrin, E. J.; Taguchi, A.; Hanash, S. M.
CANCER RESEARCH 77(16):4414-4425, 2017
Mitochondria-derived reactive oxygen species drive GANT61-induced mesothelioma cell apoptosis
Lim, C. B.
; Prele, C. M.
; Baltic, S.
; Arthur, P. G.
; Creaney, J.
; Watkins, D. N.
; Thompson, P. J.
; Mutsaers, S. E.;
Oncotarget 6(3):1519-1530, 2015
Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing
Lim, C. H.; Sun, Q.; Ratti, K.; Lee, S. H.; Zheng, Y.; Takeo, M.; Lee, W.; Rabbani, P.; Plikus, M. V.; Cain, J. E.; Wang, D. H.; Watkins, D. N.; Millar, S.; Taketo, M. M.; Myung, P.; Cotsarelis, G.; Ito, M.
Nature Communications 9(1):4903, 2018
Reduced abundance of the E3 ubiquitin ligase E6AP contributes to decreased expression of the INK4/ARF locus in non-small cell lung cancer
Gamell, C.; Gulati, T.; Levav-Cohen, Y.; Young, R. J.; Do, H.; Pilling, P.; Takano, E.; Watkins, N.; Fox, S. B.; Russell, P.; Ginsberg, D.; Monahan, B. J.; Wright, G.; Dobrovic, A.; Haupt, S.; Solomon, B.; Haupt, Y.
SCIENCE SIGNALLING 10(461):eaaf8223, 2017
The immune microenvironment, genome-wide copy number aberrations, and survival in mesothelioma
Thapa, B.; Salcedo, A.; Lin, X.; Walkiewicz, M.; Murone, C.; Ameratunga, M.; Asadi, K.; Deb, S.; Barnett, S. A.; Knight, S.; Mitchell, P.; Watkins, D. N.; Boutros, P. C.; John, T.
Journal of Thoracic Oncology 12(5):850-859, 2017
Deep multi-region whole-genome sequencing reveals heterogeneity and gene-by-environment interactions in treatment-naive, metastatic lung cancer
Leong, T. L.; Gayevskiy, V.; Steinfort, D. P.; De Massy, M. R.; Gonzalez-Rajal, A.; Marini, K. D.; Stone, E.; Chin, V.; Havryk, A.; Plit, M.; Irving, L. B.; Jennings, B. R.; McCloy, R. A.; Jayasekara, W. S. N.; Alamgeer, M.; Boolell, V.; Field, A.; Russell, P. A.; Kumar, B.; Gough, D. J.; Szczepny, A.; Ganju, V.; Rossello, F. J.; Cain, J. E.; Papenfuss, A. T.; Asselin-Labat, M. L.; Cowley, M. J.; Watkins, D. N.
ONCOGENE 38(10):1661-1675, 2019
Blockade of the IL-6 trans-signalling/STAT3 axis suppresses cachexia in Kras-induced lung adenocarcinoma
Miller, A.; McLeod, L.; Alhayyani, S.; Szczepny, A.; Watkins, D. N.; Chen, W.; Enriori, P.; Ferlin, W.; Ruwanpura, S.; Jenkins, B. J.
ONCOGENE 36:3059-3066, 2017
A phase IIa study of HA-irinotecan, formulation of hyaluronic acid and irinotecan targeting CD44 in extensive-stage small cell lung cancer
Alamgeer, M.; Watkins, D.N.; Banakh, I.; Kumar, B.; Gough, D. J.; Markman, B.; Ganju, V.
Widespread GLI expression but limited canonical hedgehog signaling restricted to the ductular reaction in human chronic liver disease
Grzelak, C. A.; Sigglekow, N. D.; Tirnitz-Parker, J. E.; Hamson, E. J.; Warren, A.; Maneck, B.; Chen, J.; Patkunanathan, B.; Boland, J.; Cheng, R.; Shackel, N. A.; Seth, D.; Bowen, D. G.; Martelotto, L. G.; Watkins, D. N.; McCaughan, G. W.
PLoS One 12(2):e0171480, 2017
Renal epithelial cells retain primary cilia during human acute renal allograft rejection injury
Verghese, E.; Martelotto, L. G.; Cain, J. E.; Williams, T. M.; Wise, A. F.; Hill, P. A.; Langham, R. G.; Watkins, D. N.; Ricardo, S. D.; Deane, J. A.
BMC Research Notes 12(1):718, 2019
In vivo evidence that RBM5 is a tumour suppressor in the lung
Jamsai, D.; Watkins, D. N.; O'Connor, A. E.; Merriner, D. J.; Gursoy, S.; Bird, A. D.; Kumar, B.; Miller, A.; Cole, T. J.; Jenkins, B. J.; O'Bryan, M. K.
Scientific Reports 7(1):16323, 2017
The tumor suppressor Hic1 maintains chromosomal stability independent of Tp53
Szczepny, A.; Carey, K.; McKenzie, L.; Jayasekara, W. S. N.; Rossello, F.; Gonzalez-Rajal, A.; McCaw, A. S.; Popovski, D.; Wang, D.; Sadler, A. J.; Mahar, A.; Russell, P. A.; Wright, G.; McCloy, R. A.; Garama, D. J.; Gough, D. J.; Baylin, S. B.; Burgess, A.; Cain, J. E.; Watkins, D. N.
ONCOGENE 37(14):1939-1948, 2018
The role of canonical and non-canonical Hedgehog signaling in tumor progression in a mouse model of small cell lung cancer
Szczepny, A.; Rogers, S.; Jayasekara, W. S. N.; Park, K.; McCloy, R. A.; Cochrane, C. R.; Ganju, V.; Cooper, W. A.; Sage, J.; Peacock, C. D.; Cain, J. E.; Burgess, A.; Watkins, D. N.
ONCOGENE 36(39):5544-5550, 2017
Genomic characterisation of small cell lung cancer patient-derived xenografts generated from endobronchial ultrasound-guided transbronchial needle aspiration specimens
Leong, T. L.
; Marini, K. D.
; Rossello, F. J.
; Jayasekara, S. N.
; Russell, P. A.
; Prodanovic, Z.
; Kumar, B.
; Ganju, V.
; Alamgeer, M.
; Irving, L. B.
; Steinfort, D. P.
; Peacock, C. D.
; Cain, J. E.
; Szczepny, A.
; Watkins, D. N.;
PLoS One 9(9):e106862, 2014
A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma
Conduit, S. E.; Ramaswamy, V.; Remke, M.; Watkins, D. N.; Wainwright, B. J.; Taylor, M. D.; Mitchell, C. A.; Dyson, J. M.
ONCOGENE 36(43):5969-5984, 2017
ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer
Saad, M. I.; Alhayyani, S.; McLeod, L.; Yu, L.; Alanazi, M.; Deswaerte, V.; Tang, K.; Jarde, T.; Smith, J. A.; Prodanovic, Z.; Tate, M. D.; Balic, J. J.; Watkins, D. N.; Cain, J. E.; Bozinovski, S.; Algar, E.; Kohmoto, T.; Ebi, H.; Ferlin, W.; Garbers, C.; Ruwanpura, S.; Sagi, I.; Rose-John, S.; Jenkins, B. J.
EMBO Molecular Medicine 11(4):e9976, 2019
Positive regulatory interactions between YAP and Hedgehog signalling in skin homeostasis and BCC development in mouse skin in vivo
Akladios, B.; Mendoza Reinoso, V.; Cain, J. E.; Wang, T.; Lambie, D. L.; Watkins, D. N.; Beverdam, A.
PLoS One 12(8):e0183178, 2017
The evolution of therapies in non-small cell lung cancer
Boolell, V.; Alamgeer, M.; Watkins, D. N.; Ganju, V.;
Cancers 7(3):1815-1846, 2015
Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy
Marini, K. D.; Croucher, D. R.; McCloy, R. A.; Vaghjiani, V.; Gonzalez-Rajal, A.; Hastings, J. F.; Chin, V.; Szczepny, A.; Kostyrko, K.; Marquez, C.; Jayasekara, W. S. N.; Alamgeer, M.; Boolell, V.; Han, J. Z. R.; Waugh, T.; Lee, H. C.; Oakes, S. R.; Kumar, B.; Harrison, C. A.; Hedger, M. P.; Lorensuhewa, N.; Kita, B.; Barrow, R.; Robinson, B. W.; de Kretser, D. M.; Wu, J.; Ganju, V.; Sweet-Cordero, E. A.; Burgess, A.; Martelotto, L. G.; Rossello, F. J.; Cain, J. E.; Watkins, D. N.
Science Translational Medicine 10(451):eaat3504, 2018
MASTL overexpression promotes chromosome instability and metastasis in breast cancer
Rogers, S.; McCloy, R. A.; Parker, B. L.; Gallego-Ortega, D.; Law, A. M. K.; Chin, V. T.; Conway, J. R. W.; Fey, D.; Millar, E. K. A.; O'Toole, S.; Deng, N.; Swarbrick, A.; Chastain, P. D.; Cesare, A. J.; Timpson, P.; Caldon, C. E.; Croucher, D. R.; James, D. E.; Watkins, D. N.; Burgess, A.
ONCOGENE 37(33):4518-4533, 2018