Cancer Developmental Biology Lab

Selected Publications

McCloy R, Parker BL, Rodgers S, Hoffman NJ, Ali N, Daly R, Watkins DN, James DE, Lorca T, Castro A, Burgess A. Global phosphoproteomic mapping of early mitotic exit in human cells identifies novel substrate dephosphorylation motifs. Mol Cell Proteomics, 2015; Aug;14(8):2194-2212. [Cover article]

Sadler AJ, Rossello FJ, Yu L, Deane JA, Yuan X, Wang D, Irving AT, Kaparakis-Liasokos M, Gantier MP, Ying H, Yim HCH, Hartland E, Notini AJ, de Boer S, White S, Mansell A, Liu J-P, Watkins DN, Gerondakis S, Williams BRG, Xu D. The BTB-ZF transcriptional regulator, PLZF, modifies chromatin to restrain inflammatory signaling programs. Proc Natl Acad Sci USA, 2015 Feb 3;112(5):1535-40

Lim Y, Gondek L, Wang Q, Ma H, Chang E, Huso DL, Foerster S, Marchionni L, McGovern K, Watkins DN, Peacock CD, Levis M, Smith BD, Merchant AA, Small D, Matsui W. Integration of Hedgehog and mutant FLT3 signaling in myeloid leukemia. Sci Transl Med, 2015; 7:291ra96. [Reviewed in “Research Watch”, Cancer Discov, 2015 Jun 18.]

Wang DH, Tiwari A, Kim ME, Clemons NJ, Regmi NL, Hodges WA, Berman DM, Montgomery EA, Watkins DN, Zhang X, Zhang Q, Jie C, Spechler SJ, Souza RF. Hedgehog signaling regulates Foxa2 in esophageal embryogenesis and Barrett’s metaplasia. J Clin Invest, 2014; 2;124(9):3767-80

Leong TL, Marini KD, Rossello FJ, Jayesekara SN, Russell PA, Prodanovic Z, Kumar B, Ganju V, Alamgeer M, Irving LB, Steinfort DP, Peacock CD, Cain JE, Szczepny A, Watkins DN. Genomic Characterisation of Small Cell Lung Cancer Patient-Derived Xenografts Generated from Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration Specimens. PloS One, 2014; 9(9):e106862

Alamgeer M, Ganju V, Kumar B, Fox J, Hart S, White M, Harris M, Stuckey J, Prodanovic Z, Schneider M, Watkins DN. Changes in ALDEHYDE DEHYDROGENASE-1 (ALDH1) expression during neoadjuvant chemotherapy predict outcome in locally advanced breast cancer. Breast Cancer Res, 2014; 16:R44.

Alamgeer M, Ganju V, Szczepny A, Russell PA, Prodanovic Z, Kumar B, Wainer Z, Brown T, Schneider-Kosky M, Conron M, Wright G, Watkins DN. The prognostic significance of aldehyde dehydrogenase 1A1 (ALDH1A1) and CD133 expression in early-stage non-small cell lung cancer. Thorax, 2013; 68(12):1095-104.

O'Toole SA, Machalek DA, Shearer RF, Millar EKA, Nair R, Schofield P, McLeod D, Cooper CL, McNeil CM, McFarland A, Nguyen A, Ormandy CJ, Qiu MR, Rabinovich B, Martelotto LG, Vu D, Hannigan GE, Musgrove EA, Christ D, Sutherland RL, Watkins DN*, Swarbrick A*. Hedgehog Overexpression Is Associated with Stromal Interactions and Predicts for Poor Outcome in Breast Cancer. Cancer Res, 2011; 71:4002-4014.*Co-corresponding author.

Park KS, Martelotto LG, Peifer M, Sos ML, Karnezis AN, Mahjoub MR, Bernard K, Conklin J, Szczepny A, Yuan J, Guo R, Ospina B, Falzon J, Bennett S, Brown TL, Markovic A, Devereux WL, Ocasio CR, Chen JK, Stearns T, Dorsch M, Buonamici S, Watkins DN, Peacock CD, Sage J.  A critical requirement for Hedgehog signalling in small cell lung cancer.  Nat Med, 2011; 17:1504-1509. [Featured in Cancer Discovery “Research Watch”, October 21, 2011]

Wang DH, Clemons NJ, Miyashita T, Dupuy, AJ, Zhang, W, Szczepny A, Corcoran-Schwartz IM, Wilburn DL, Montgomery EA, Wang JS, Jenkins NA, Copeland N, Harmon JW, Phillips WA, Watkins DN.  Aberrant Epithelial-Mesenchymal Hedgehog Signalling Characterizes Barrett's Metaplasia.  Gastroenterology, 2010; 138:1810–1822.


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