Cellular Immunity Lab

Selected Publications

Webster K, Kim H-O, Kyparissoudis K, Corpuz TM, Pinget GV, Brink R,Belz,G, Cho J-H, Godfrey DI, Sprent J.  IL-17-producing NKT cells depend exclusively on IL-7 for homeostasis and survival. Mucosal Immunol 2013; in press

Boyman O and Sprent J. The role of interleukin-2 during homeostasis and activation of the immune system. Nature Rev Immunol 2012; 12:180-90.

Surh CD and Sprent J. TGFb puts the brakes on homeostatic proliferation. Nat Immunol  2012; 13:628-30.

Sprent J and Surh CD. Normal T cell homeostasis: the conversion of naïve cells into memory-phenotype cells. Nat Immunol 2011; 12:478-84.

Cho J-H, Kim H-O, Surh CD, Sprent J. TCR-dependent regulatory lipid rafts controls naïve CD8+ homeostasis. Immunity 2010; 32:214-226.

Webster KE, Walters S, Kohler RE, Mrkvan T, Boyman O, Surh CD, Grey ST, Sprent J. In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression. J. Exp. Med. 2009; 206:751-60.

Surh CD, Sprent J. Homeostasis of naïve and memory T cells. Immunity 2008; 29:848-862.

Boyman O, Purton JF, Surh CD, Sprent J. Cytokines and T-cell homeostasis. Curr Opin Immunol 2007; 19:320-26.

Purton JF, Tan JT, Rubinstein MP, Kim DM, Sprent J, Surh CD. Antiviral CD4+ memory T cells are IL-15 dependent. J Exp Med 2007; 204(4):951-61.

Boyman O, Kovar M, Rubinstein MP, Surh CD, Sprent J. Selective stimulation of T cell subsets with antibody-cytokine immune complexes. Science 2006; 311(5769):1924-7.

Ishimaru N, Kishimoto H, Hayashi Y, Sprent J. Regulation of naive T cell function by the NF-kappaB2 pathway. Nat Immunol 2006; 7(7):763-72.

Surh CD, Sprent J. On the TRAIL of homeostatic memory T cells. Nat Immunol 2006; 7(5):439-41.

Rubinstein MP, Kovar M, Purton JF, Cho JH, Boyman O, Surh CD, Sprent J. Converting IL-15 to a superagonist by binding to soluble IL-15Ralpha. Proc Natl Acad Sci USA 2006; 103(24):9166-71.

Kovar M, Boyman O, Shen X, Hwang I, Kohler R, Sprent J. Direct stimulation of T cells by membrane vesicles from antigen-presenting cells. Proc Natl Acad Sci USA 2006; 103(31):11671-6.

Boyman O, Cho JH, Tan JT, Surh CD, Sprent J. A major histocompatibility complex class I-dependent subset of memory phenotype CD8+ cells. J Exp Med 2006; 203(7):1817-25.



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