Genetic Epidemiology of Osteoporosis Lab

Selected Publications

Chan MY, Frost SA, Center JR, Eisman JA, Nguyen TV. Relationship between body mass index and fracture risk is mediated by bone mineral density. J Bone Miner Res. 2014 Nov;29(11):2327-35. 

Ho-Pham LT, Nguyen U, Nguyen TV. Association between lean mass, fat mass and bone mineral density: a meta-analysis. J Clin Endocrinol Metab 2014; 99:30-8. 

Yang S, Nguyen ND, Center JR, Eisman JA, Nguyen TV. Association between abdominal obesity and fracture risk: a prospective study. J Clin Endocrinol Metab. 2013;98(6):2478-83. 

Styrkarsdottir U, Thorleifsson G, Sulem P, Gudbjartsson DF, Sigurdsson A, Jonasdottir A, Jonasdottir A, Oddsson A, Helgason A, Magnusson OT, Walters GB, Frigge ML, Helgadottir HT, Johannsdottir H, Bergsteinsdottir K, Ogmundsdottir MH, Center JR, Nguyen TV, Eisman JA, Christiansen C, Steingrimsson E, Jonasson JG, Tryggvadottir L, Eyjolfsson GI, Theodors A, Jonsson T, Ingvarsson T, Olafsson I, Rafnar T, Kong A, Sigurdsson G, Masson G, Thorsteinsdottir U, Stefansson K. Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits. Nature. 2013;497(7450):517-20.

Nguyen HT, von Schoultz B, Nguyen TV, Dzung DN, Duc PT, Thuy VT, Hirschberg AL. Vitamin D deficiency in northern Vietnam: Prevalence, risk factors and associations with bone mineral density. Bone 2012; 51(6):1029-34.

Yang S, Nguyen ND, Eisman JA, Nguyen TV. Association between beta-blockers and fracture risk: A Bayesian meta-analysis. Bone 2012; 51(5):969-74.

Chan MY, Nguyen ND, Center JR, Eisman JA, Nguyen TV. Quantitative ultrasound and fracture risk prediction in non-osteoporotic men and women as defined by WHO criteria. Osteoporosis Int. 2012; Aug 10. [Epub ahead of print].

Tran BN, Nguyen ND, Nguyen VX, Center JR, Eisman JA, Nguyen TV. Genetic profiling and individualized prognosis of fracture. J Bone Miner Res 2011; 26(2):414-9.

Center JR, Bliuc D, Nguyen ND, Nguyen TV, Eisman JA. Osteoporosis medication and reduced mortality risk in elderly women and men. J Clin Endocrinol Metab 2011; 96(4):1006-14.

Langsetmo L, Nguyen TV, Nguyen ND, Kovacs CS, Prior JC, Center JR, Morin S, Josse RG, Adachi JD, Hanley DA, Eisman JA; Canadian Multicentre Osteoporosis Study Research Group. Independent external validation of nomograms for predicting risk of low-trauma fracture and hip fracture. CMAJ 2011; 183(2):E107-14.

van Geel TA, Nguyen ND, Geusens PP, Center JR, Nguyen TV, Dinant GJ, Eisman JA. Development of a simple prognostic nomogram for individualising 5-year and 10-year absolute risks of fracture: a population-based prospective study among postmenopausal women. Ann Rheum Dis 2011; 70(1):92-7.

Ho-Pham LT, Nguyen ND, Lai TQ, Eisman JA, Nguyen TV. Vitamin D status and parathyroid hormone in a urban population in Vietnam. Osteoporos Int. 2011; 22(1):241-8.

Sandhu SK, Nguyen ND, Center JR, Pocock NA, Eisman JA, Nguyen TV. Prognosis of fracture: evaluation of predictive accuracy of the FRAX algorithm and Garvan nomogram. Osteoporos Int. 2010; 21(5):863-71.

Bliuc D, Nguyen ND, Milch VE, Nguyen TV, Eisman JA, Center JR. Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and women. JAMA. 2009;301(5):513-21.

Styrkarsdottir U, Halldorsson BV, Gretarsdottir S, Gudbjartsson DF, Walters GB, Ingvarsson T, Jonsdottir T, Saemundsdottir J, Snorradóttir S, Center JR, Nguyen TV, Alexandersen P, Gulcher JR, Eisman JA, Christiansen C, Sigurdsson G, Kong A, Thorsteinsdottir U, Stefansson K. New sequence variants associated with bone mineral density. Nat Genet. 2009;41(1):15-7.

Frost SA, Nguyen ND, Center JR, Eisman JA, Nguyen TV. Timing of repeat BMD measurements: development of an absolute risk-based prognostic model. J Bone Miner Res. 2009; 24(11):1800-7.

Tran BN, Nguyen ND, Eisman JA, Nguyen TV. Association between LRP5 polymorphism and bone mineral density: a Bayesian meta-analysis. BMC Med Genet. 2008; 27:9:55.

Nguyen ND, Frost SA, Center JR, Eisman JA, Nguyen TV. Development of prognostic nomograms for individualizing 5-year and 10-year fracture risks. Osteoporos Int. 2008; 19(10):1431-44.

Nguyen ND, Frost SA, Center JR, Eisman JA, Nguyen TV.Development of a nomogram for individualizing hip fracture risk in men and women. Osteoporos Int. 2007; 18(8):1109-17.

Center JR, Bliuc D, Nguyen TV, Eisman JA. Risk of subsequent fracture after low-trauma fracture in men and women. JAMA. 2007; 297(4):387-94.

Nguyen ND, Eisman JA, Nguyen TV. Anti-hip fracture efficacy of biophosphonates: a Bayesian analysis of clinical trials. J Bone Miner Res 2006; 21(2):340-9.

Nguyen ND, Pongchaiyakul C, Center JR, Eisman JA, Nguyen TV. Identification of high-risk individuals for hip fracture: a 14-year prospective study. J Bone Miner Res 2005; 20(11):1921-8.

Nguyen TV, Esteban LM, White CP, Grant SF, Center JR, Gardiner EM, Eisman JA. Contribution of the collagen I alpha1 and vitamin D receptor genes to the risk of hip fracture in elderly women. J Clin Endocrinol Metab 2005; 90(12):6575-9.

Nguyen TV, Livshits G, Center JR, Yakovenko K, Eisman JA. Genetic determination of bone mineral density: evidence for a major gene. J Clin Endocrinol Metab 2003; 88(8):3614-20.

Nguyen TV, Center JR, Sambrook PN, Eisman JA.  Risk factors for proximal humerus, forearm and wrist fractures in elderly men and women: The Dubbo Osteoporosis Epidemiology Study.  Am J Epidemiol 2001; 153:587-595.

Nguyen TV, Center JR, Eisman JA.  Association between breast cancer and bone mineral density: The Dubbo Osteoporosis Epidemiology Study.  Maturitas 2000; 36:27-34.

Nguyen TV, Eisman JA. On the assessment of significant change in BMD for an individual.  J Bone Miner Res 2000; 15:369-72.

Center JR, Nguyen TV, Schneider D, Sambrook PN, Eisman JA. Mortality after all major types of osteoporotic fracture in men and women: an observational study. Lancet 1999; 353:878-82.

Nguyen TV, Sambrook PN, Eisman JA. Bone loss, physical activity, and weight change in elderly women: The Dubbo Osteoporosis Epidemiology Study. J Bone Miner Res 1998; 13:1458-1467.

Nguyen TV, Eisman JA, Kelly PJ, Sambrook PN. Risk factors for osteoporotic fractures in men. Am J Epidemiol 1996;144:255-263.

Riggs BL, Nguyen TV, Melton LJ III, Morrison NA, O'Fallon WM, Kelly PJ, Egan KS, Sambrook PN, Muhs JM, Eisman JA. The contribution of vitamin D receptor gene alleles to bone mineral density in normal and osteoporotic women. J Bone Miner Res 1995; 10:991-996.

Nguyen TV, Jones G, Sambrook PN, Kelly PJ, White CP and Eisman JA. The effects of estrogen exposure and reproductive factors on bone mineral density and osteoporotic fractures. J Clin Endocrinol Metab 1994; 9:2709-2714.

Jones G, Nguyen TV, Sambrook PN, Kelly PJ, Eisman JA. Progressive loss of bone in the femoral neck in elderly people: longitudinal findings from the Dubbo Osteoporosis Epidemiology Study. Br Med J 1994 309:691-695.

Nguyen TV, Sambrook PN, Kelly PJ, Jones G, Gilbert C, Lord S, Freund J, Eisman JA. Prediction of osteoporotic fractures by postural instability and bone density. Br Med J 1993; 307:1111-1115.

Sambrook PN,  Birmingham J, Kelly PJ, Kempler S, Nguyen T, Pocock N, Eisman JA. Prevention of corticosteroid osteoporosis: a comparison of calcium, calcitriol and calcintonin. N Engl J Med 1993; 328:1747-1752.

More Garvan Publications