Genomic Cancer Medicine
My lab is interested in the germline and somatic genetics of cancers with poor outcomes, and particularly those affecting the young. While we tackle all cancers, we have a particular focus on sarcomas. Sarcomas are devastating cancers arising in the connective tissues – bone, muscle, fat, and cartilage – and which often occur in children and young adults.
We use patient-centred approaches to understanding why cancers happen, coupled with experimental systems to explore the biological and therapeutic implications of our clinical discoveries. We have developed some of the world's largest cohorts of patients and families affected by cancer, to which we apply state-of-the-art genomic technologies and creative clinical interventions, with the goal of improving health outcomes.
Our goal is to bring the power of science to benefit patients and their families. Examples of our efforts to improve health outcomes are:
- a whole-body MRI program for risk modification for individuals who have a high genetic risk; and
- an innovative clinical basket-umbrella trial to test new therapies based on genomic biomarkers.