Innate and Tumour Immunology Lab

Selected Publications

A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts. Nobis M, Herrmann D, Warren SC, Kadir S, Leung W, Killen M, Magenau A, Stevenson D, Lucas MC, Reischmann N, Vennin C, Conway JRW, Boulghourjian A, Zaratzian A, Law AM, Gallego-Ortega D, Ormandy CJ, Walters SN, Grey ST, Bailey J, Chtanova T, Quinn JMW, Baldock PA, Croucher PI, Schwarz JP, Mrowinska A, Zhang L, Herzog H, Masedunskas A, Hardeman EC, Gunning PW, Del Monte-Nieto G, Harvey RP, Samuel MS, Pajic M, McGhee EJ, Johnsson AE, Sansom OJ, Welch HCE, Morton JP, Strathdee D, Anderson KI, Timpson P. Cell Rep. 2017 Oct 3;21(1):274-288. doi: 10.1016/j.celrep.2017.09.022.

Regulatory T cells with superior immunosuppressive capacity emigrate from the inflamed colon to draining lymph nodes. Nakanishi Y, Ikebuchi R, Chtanova T, Kusumoto Y, Okuyama H, Moriya T, Honda T, Kabashima K, Watanabe T, Sakai Y, Tomura M. Mucosal Immunol. 2017 Aug 2. doi: 10.1038/mi.2017.64. [Epub ahead of print]

In vivo photolabeling of tumor-infiltrating cells reveals highly regulated egress of T-cell subsets from tumors. Torcellan T, Hampton HR, Bailey J, Tomura M, Brink R, Chtanova T. Proc Natl Acad Sci USA. May 2017. 114(22) 5677-5682.

In Vivo Imaging Sheds Light on Immune Cell Migration and Function in Cancer. Torcellan T, Stolp J, Chtanova T. Front Immunol. March 2017; 8:309.

Leukocyte Motility Models Assessed through Simulation and Multi-objective Optimization-Based Model Selection. Read MN, Bailey J, Timmis J, Chtanova T. PLoS Comput Biol. 2016 Sep 2;12(9):e1005082. doi: 10.1371/journal.pcbi.1005082. eCollection 2016 Sep. 

 Hampton H, Chtanova T. The Lymph node neutrophil. Seminars in Immunology April 2016; 28(2) 129-136

Gallego-Ortega D, Ledger A, Roden DL, Law AM, Magenau A, Kikhtyak Z, Cho C, Allerdice SL, Lee HJ, Valdes-Mora F, Herrmann D, Salomon R, Young AI, Lee BY, Sergio CM, Kaplan W, Piggin C, Conway JR, Rabinovich B, Millar EK, Oakes SR, Chtanova T, Swarbrick A, Naylor MJ, O'Toole S, Green AR, Timpson P, Gee JM, Ellis IO, Clark SJ, Ormandy CJELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells. PLoS Biol. 2015 Dec 30;13(12):e1002330. doi: 10.1371/journal.pbio.1002330.

Suan D, Nguyen A, Moran I, Bourne K, Hermes J, Hampton HR, Tomura M, Miwa Y, Kelleher AD, Kaplan W, Deenick EK, Tangye SG, Brink R, Chtanova T, Phan TG. T follicular helper celles have distinct modes of migration and molecular signatures in naive and memory immune responses. Immunity 2015; 42(4):704-18 

Hampton HR,  Bailey J, Brink R, Chtanova T. Microbe-dependent lymphatic migration of neutrophils modulates lymphocyte proliferation in lymph nodes. Nat Commun 2015; 6:7139.

Suan, D.; Hampton, H. R.; Tomura, M.; Kanagawa, O.; Chtanova, T.; Phan, T. G.Optimizing fluorescence excitation and detection for intravital two-photon microscopy. Methods Cell Biol  2013; 113:311-323.

Chtanova T, Hampton HR, Waterhouse LA, Wood K, Tomura M, Miwa Y, Mackay CR, Brink R, Phan TG. Real-time interactive two-photon photoconversion of recirculating lymphocytes for discontinuous cell tracking in live adult mice. J Biophotonics 2012; Nov 26. doi: 10.1002/jbio.201200175

Phan TG and Chtanova T. Lymphocyte activation - Border patrol: SCS macrophages activate iNKT cells too. Immunology and Cell Biology. 2010; 88(6):619-21.

Chtanova T, Han S-J, Schaeffer M, van Dooren G, Herzmark P, Striepen B, and Robey EA. Dynamics of T cell, antigen presenting cell, and pathogen interactions during recall responses in the lymph node. Immunity: 2009; 31(2):342-55.

Schaeffer M, Han S-J, Chtanova T, van Dooren G, Herzmark P, Chen Y, Roysam B, Striepen B, and Robey EA. Dynamic imaging of T cell - parasite interactions in the brains of mice chronically infected with Toxoplasma gondi. J Immunol. 2009; 182:6379.

Chtanova T, Schaeffer M, Han S-J, van Dooren G, Striepen B, Herzmark P, Camfield K, Nollmann M, Aaron H, and Robey EA. Dynamics of neutrophil migration in lymph nodes during Toxoplasma gondii infection. Immunity 2008; 29:487.

Ladi E, Schwickert TA, Chtanova T, Chen Y, Herzmark P, Yin X, Aaron H, Chan SW, Lipp M, Roysam B, Robey EA. Thymocyte-dendritic cell interactions near sources of CCR7 ligands in the thymic cortex. J Immunol 2008; 181:7014.

Liu SM, Xavier R, Good KL, Chtanova T, Newton R, Sisavanh M, Zimmer S, Deng C, Silva DG, Frost MJ, Tangye SG, Rolph MS, Mackay CR. Immune cell transcriptome datasets reveal novel leukocyte subset-specific genes and genes associated with allergic processes. J Allergy Clin Immunol. 2006; 118(2):496.

Ladi E, Chtanova T, Yin X, Robey EA. Thymic microenvironments for T cell differentiation and selection. Nat Immunol. 2006; 7(4):338. Review.

Yin X, Ladi E, Chtanova T, Robey EA. Thymocyte motility: mutants, movies and migration patterns. Curr Opin Immunol. 2006; 18(2):191. Review.

Chtanova T, Newton R, Liu SM, Weininger L, Young TR, Silva DG, Bertoni F, Rinaldi A, Chappaz S, Sallusto F, Rolph MS, Mackay CR. Identification of T cell-restricted genes, and signatures for different T cell responses, using a comprehensive collection of microarray datasets. J Immunol. 2005; 175:7837.

Chtanova T, Tangye SG, Newton RA, Frank N, Hodge MR, Rolph MS, Mackay CR. T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells. J Immunol 2004; 173:68.

Ng LG, Sutherland APR, Newton RA, Qian F, Cachero TG, Scott M, Thompson JS, Wheway J, Chtanova T, Xin C, Groom J, Tangye SG, Kalled SL, Mackay F, Mackay CR. BAFF-R is the principal BAFF receptor facilitating BAFF co-stimulation of B and T cells. J Immunol 2004; 174:807.

Chtanova T, and Mackay CR. T cell effector subsets: extending the Th1/Th2 paradigm. Adv Immunol 2001; 78:233. Review.

Chtanova T, Kemp RA, Sutherland AP, Ronchese F, Mackay CR. Gene microarrays reveal extensive differential gene expression in both CD4+ and CD8+ type 1 and type 2 T cells. J Immunol 2001; 167:3057.

More Garvan Publications