Islet Biology Lab


A fluorescent timer reporter enables sorting of insulin secretory granules by age
Yau, B.; Hays, L.; Liang, C.; Laybutt, D. R.; Thomas, H. E.; Gunton, J. E.; Williams, L.; Hawthorne, W. J.; Thorn, P.; Rhodes, C. J.; Kebede, M. A.
Failure of the adaptive unfolded protein response in islets of obese mice is linked with abnormalities in beta-cell gene expression and progression to diabetes
Chan, J. Y.; Luzuriaga, J.; Bensellam, M.; Biden, T. J.; Laybutt, D. R.
DIABETES 62(5):1557-68, 2013
Epidemics will always come (and go): The need to prepare for the next one, research on COVID-19, and the role of molecular and cellular endocrinology
Stratakis, C. A.; Laybutt, D. R.; Laudet, V.; Klinge, C. M.
A Reevaluation of the Role of the Unfolded Protein Response in Islet Dysfunction: Maladaptation or a Failure to Adapt?
Herbert, T. P.; Laybutt, D. R.;
DIABETES 65(6):1472-80, 2016
Metallothionein 1 negatively regulates glucose-stimulated insulin secretion and is differentially expressed in conditions of beta cell compensation and failure in mice and humans
Bensellam, M.; Shi, Y. C.; Chan, J. Y.; Laybutt, D. R.; Chae, H.; Abou-Samra, M.; Pappas, E. G.; Thomas, H. E.; Gilon, P.; Jonas, J. C.
DIABETOLOGIA 62(12):2273-2286, 2019
Identification of islet-enriched long non-coding RNAs contributing to β-cell failure in type 2 diabetes.
Motterle, A, Gattesco, S, Peyot, M-L, Esguerra, J.L.S, Gomez-Ruiz, A, Laybutt, D.R, Gilon, P, Burdet, F, Ibberson, M, Eliasson, L, Prentki, M, Regazzi, R.
Molecular Metabolism 6:1407-1418, 2017
The influence of genetic background on the induction of oxidative stress and impaired insulin secretion in mouse islets
Zraika, S.;Aston-Mourney, K.;Laybutt, D. R.;Kebede, M.;Dunlop, M. E.;Proietto, J.;Andrikopoulos, S. :
DIABETOLOGIA 49(6):1254-63, 2006
Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes
Laybutt, D. R.;Preston, A. M.;Akerfeldt, M. C.;Kench, J. G.;Busch, A. K.;Biankin, A. V.;Biden, T. J. :
DIABETOLOGIA 50(4):752-63, 2007
Contribution of the Long Non-Coding RNA H19 to Neonatal and Adult Rodent beta-Cell Mass Expansion
Sanchez-Parra, C.; Jacovetti, C.; Dumortier, O.; Lee, K.; Peyot, M. L.; Guay, C.; Prentki, M.; Laybutt, D. R.; Van Obberghen, E.; Regazzi, R.
DIABETES 67(11):2254-2267, 2018
Phlda3 regulates beta cell survival during stress
Bensellam, M.; Chan, J. Y.; Lee, K.; Joglekar, M. V.; Hardikar, A. A.; Loudovaris, T.; Thomas, H. E.; Jonas, J. C.; Laybutt, D. R.
Scientific Reports 9(1):12827, 2019
Emerging Roles of Metallothioneins in Beta Cell Pathophysiology: Beyond and Above Metal Homeostasis and Antioxidant Response
Bensellam, M.; Laybutt, D. R.; Jonas, J. C.
Biology (Basel) 10(3):176, 2021
On-target action of anti-tropomyosin drugs regulates glucose metabolism
Kee, A. J.; Chagan, J.; Chan, J. Y.; Bryce, N. S.; Lucas, C. A.; Zeng, J.; Hook, J.; Treutlein, H.; Laybutt, D. R.; Stehn, J. R.; Gunning, P. W.; Hardeman, E. C.
Scientific Reports 8(1):4604, 2018
Mechanisms of beta-cell dedifferentiation in diabetes: recent findings and future research directions
Bensellam, M.; Jonas, J. C.; Laybutt, D. R.
Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes
Kjorholt, C.;Akerfeldt, M. C.;Biden, T. J.;Laybutt, D. R. :
DIABETES 54(9):2755-63, 2005
Critical reduction in beta-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes
Laybutt, D. R.;Glandt, M.;Xu, G.;Ahn, Y. B.;Trivedi, N.;Bonner-Weir, S.;Weir, G. C. :
Transcriptome analysis of islets from diabetes-resistant and diabetes-prone obese mice reveals novel gene regulatory networks involved in beta-cell compensation and failure
Chan, J. Y.; Bensellam, M.; Lin, R. C. Y.; Liang, C.; Lee, K.; Jonas, J. C.; Laybutt, D. R.
FASEB JOURNAL 35(6):e21608, 2021
Loss-of-function of the long non-coding RNA A830019P07Rik in mice does not affect insulin expression and secretion
Guay, C.; Abdulkarim, B.; Tan, J. Y.; Dubuis, G.; Rutti, S.; Ross Laybutt, D.; Widmann, C.; Regazzi, R.; Marques, A. C.
Scientific Reports 10(1):6413, 2020
Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic beta-cells from lipoapoptosis
Busch, A. K.;Gurisik, E.;Cordery, D. V.;Sudlow, M.;Denyer, G. S.;Laybutt, D. R.;Hughes, W. E.;Biden, T. J. :
DIABETES 54(10):2917-24, 2005
Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes
Xu, G.;Kaneto, H.;Laybutt, D. R.;Duvivier-Kali, V. F.;Trivedi, N.;Suzuma, K.;King, G. L.;Weir, G. C.;Bonner-Weir, S. :
DIABETES 56(6):1551-8, 2007
Circular RNAs as novel regulators of beta-cell functions in normal and disease conditions
Stoll, L.; Sobel, J.; Rodriguez-Trejo, A.; Guay, C.; Lee, K.; Veno, M. T.; Kjems, J.; Laybutt, D. R.; Regazzi, R.
Molecular Metabolism 9:69-83, 2018