Matrix and Metastasis


Proteomic Characterization of Caenorhabditis elegans Larval Development
Xia, T.; Horton, E. R.; Salcini, A. E.; Pocock, R.; Cox, T. R.; Erler, J. T.
PROTEOMICS 18(2) 2018
Charting the unexplored extracellular matrix in cancer
Filipe, E. C.; Chitty, J. L.; Cox, T. R.
The Role of the ECM in Lung Cancer Dormancy and Outgrowth
Parker, A. L.; Cox, T. R.
Frontiers in Oncology 10:1766, 2020
Towards engineering heart tissues from bioprinted cardiac spheroids
Polonchuk, L.; Surija, L.; Lee, M. H.; Sharma, P.; Liu Chung Ming, C.; Richter, F.; Ben-Sefer, E.; Rad, M. A.; Mahmodi Sheikh Sarmast, H.; Shamery, W. A.; Tran, H. A.; Vettori, L.; Haeusermann, F.; Filipe, E. C.; Rnjak-Kovacina, J.; Cox, T.; Tipper, J.; Kabakova, I.; Gentile, C.
Biofabrication 13(4) 2021
Pirfenidone Reduces Epithelial-Mesenchymal Transition and Spheroid Formation in Breast Carcinoma through Targeting Cancer-Associated Fibroblasts (CAFs)
Es, H. A.; Cox, T. R.; Sarafraz-Yazdi, E.; Thiery, J. P.; Warkiani, M. E.
Cancers (Basel) 13(20):5118, 2021
MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition
Coll, R. C.; Hill, J. R.; Day, C. J.; Zamoshnikova, A.; Boucher, D.; Massey, N. L.; Chitty, J. L.; Fraser, J. A.; Jennings, M. P.; Robertson, A. A. B.; Schroder, K.
Nature Chemical Biology 15(6):556-559, 2019
Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer
Chang, J.; Lucas, M. C.; Leonte, L. E.; Garcia-Montolio, M.; Singh, L. B.; Findlay, A. D.; Deodhar, M.; Foot, J. S.; Jarolimek, W.; Timpson, P.; Erler, J. T.; Cox, T. R.
Oncotarget 8(16):26066-26078, 2017
LOXL1 is regulated by Integrin alpha11 and promotes Non-Small Cell Lung Cancer tumorigenicity
Zeltz, C.; Pasko, E.; Cox, T. R.; Navab, R.; Tsao, M. S.
Cancers 11(5):705, 2019
Tumor endothelial marker 8 promotes cancer progression and metastasis
Hoye, A. M.; Tolstrup, S. D.; Horton, E. R.; Nicolau, M.; Frost, H.; Woo, J. H.; Mauldin, J. P.; Frankel, A. E.; Cox, T. R.; Erler, J. T.
Oncotarget 9(53):30173-30188, 2018
Proteomic profiling of human prostate cancer-associated fibroblasts (CAF) reveals LOXL2-dependent regulation of the tumor microenvironment.
Nguyen, E. V.; Pereira, B. A.; Lawrence, M. G.; Ma, X.; Rebello, R. J.; Chan, H.; Niranjan, B.; Wu, Y.; Ellem, S.; Guan, X.; Wu, J.; Skhinas, J. N.; Cox, T. R.; Risbridger, G. P.; Taylor, R. A.; Lister, N. L.; Daly, R. J.
The interplay between extracellular matrix remodelling and kinase signalling in cancer progression and metastasis
Skhinas, J. N.; Cox, T. R.
Cell Adhesion & Migration :, 2017
The role of the extracellular matrix and the heparan sulfate proteoglycan Perlecan
Elgundi, Z.; Papanicolaou, M.; Major, G.; Cox, T. R.; Melrose, J.; Whitelock, J. M.; Farrugia, B. L.
Frontiers in Oncology 9:1482, 2020
Plasma polymerized nanoparticles effectively deliver dual siRNA and drug therapy in vivo
Michael, P.; Lam, Y. T.; Filipe, E. C.; Tan, R. P.; Chan, A. H. P.; Lee, B. S. L.; Feng, N.; Hung, J.; Cox, T. R.; Santos, M.; Wise, S. G.
Scientific Reports 10(1):12836, 2020
Correlation of ultrasound shear wave elastography with pathological analysis in a xenografic tumour model
Elyas, E.; Papaevangelou, E.; Alles, E. J.; Erler, J. T.; Cox, T. R.; Robinson, S. P.; Bamber, J. C.
Scientific Reports 7(1):165, 2017
The extracellular matrix as a key regulator of intracellular signalling networks
Hastings, J. F.; Skhinas, J. N.; Fey, D.; Croucher, D. R.; Cox, T. R.
ISDoT: in situ decellularization of tissues for high-resolution imaging and proteomic analysis of native extracellular matrix
Mayorca-Guiliani, A. E.; Madsen, C. D.; Cox, T. R.; Horton, E. R.; Venning, F. A.; Erler, J. T.
NATURE MEDICINE 23(7):890-898, 2017
Cancer cells' ability to mechanically adjust to extracellular matrix stiffness correlates with their invasive potential
Wullkopf, L.; West, A. V.; Leijnse, N.; Cox, T. R.; Madsen, C. D.; Oddershede, L. B.; Erler, J. T.
MOLECULAR BIOLOGY OF THE CELL 29(20):2378-2385, 2018
Pre-metastatic niches: organ-specific homes for metastases
Peinado, H.; Zhang, H.; Matei, I. R.; Costa-Silva, B.; Hoshino, A.; Rodrigues, G.; Psaila, B.; Kaplan, R. N.; Bromberg, J. F.; Kang, Y.; Bissell, M. J.; Cox, T. R.; Giaccia, A. J.; Erler, J. T.; Hiratsuka, S.; Ghajar, C. M.; Lyden, D.
NATURE REVIEWS CANCER 17(5):302-317, 2017
Dynamic rearrangement of cell states detected by systematic screening of sequential anticancer treatments
Koplev, S.; Longden, J.; Ferkinghoff-Borg, J.; Blicher Bjerregard, M.; Cox, T. R.; Erler, J. T.; Pedersen, J. T.; Voellmy, F.; Sommer, M. O. A.; Linding, R.
Cell Reports 20(12):2784-2791, 2017
The matrix in cancer
Cox, T. R.
NATURE REVIEWS CANCER 21(4):217-238, 2021
The importance of developing therapies targeting the biological spectrum of metastatic disease
Zijlstra, A.; Von Lersner, A.; Yu, D.; Borrello, L.; Oudin, M.; Kang, Y.; Sahai, E.; Fingleton, B.; Stein, U.; Cox, T. R.; Price, J. T.; Kato, Y.; Welm, A. L.; Aguirre-Ghiso, J. A.; Board Members of the Metastasis Research, Society
Meeting report: Metastasis Research Society (MRS) 17th Biennial conference and associated Young Investigator Satellite Meeting (YISM) on cancer metastasis
Beadnell, T.; Borriello, L.; Christenson, J.; Fornetti, J.; Guldner, I.; Hanna, A.; Kyjacova, L.; Marinak-Whately, K.; de Melo Martins, P. C.; Rotinen, M.; Te Boekhorst, V.; Cox, T. R.
Meeting report: Metastasis Research Society-Chinese Tumor Metastasis Society joint conference on metastasis
Bankaitis, K.; Borriello, L.; Cox, T.; Lynch, C.; Zijlstra, A.; Fingleton, B.; Guzvic, M.; Anderson, R.; Neman, J.
In Vitro 3D Models of Tunable Stiffness
Filipe, E. C.; Parker, A. L.; Cadell, A. L.; Major, G.; Croucher, D. R.; Cox, T. R.
Methods in Molecular Biology 2294:27-42, 2021
Established models and new paradigms for hypoxia-driven cancer-associated bone disease
Cox, T. R.; Erler, J. T.; Rumney, R. M. H.
The Mini-Organo: A rapid high-throughput 3D coculture organotypic assay for oncology screening and drug development
Chitty, J. L.; Skhinas, J. N.; Filipe, E. C.; Wang, S.; Cupello, C. R.; Grant, R. D.; Yam, M.; Papanicolaou, M.; Major, G.; Zaratzian, A.; Da Silva, A. M.; Tayao, M.; Vennin, C.; Timpson, P.; Madsen, C. D.; Cox, T. R.
Cancer Reports 3(1):e1209, 2020
Altered processing enhances the efficacy of small-diameter silk fibroin vascular grafts
Chan, A. H. P.; Filipe, E. C.; Tan, R. P.; Santos, M.; Yang, N.; Hung, J.; Feng, J.; Nazir, S.; Benn, A. J.; Ng, M. K. C.; Rnjak-Kovacina, J.; Wise, S. G.
Scientific Reports 9(1):17461, 2019
Bioactive materials facilitating targeted local modulation of inflammation
Tan, R. P.; Chan, A. H. P.; Wei, S.; Santos, M.; Lee, B. S. L.; Filipe, E. C.; Akhavan, B.; Bilek, M. M.; Ng, M. K. C.; Xiao, Y.; Wise, S. G.
JACC: Basic to Translational Science 4(1):56-71, 2019