Neurotranscriptomics Lab

Selected Publications

Avgan NWang JI, Fernandez-Chamorro J, Weatheritt RJ. Multilayered control of exon acquisition permits the emergence of novel forms of regulatory control. Genome Biology. 2019 Jul 17;20(1):141.

Gueroussov S*, Weatheritt RJ*, O'Hanlon D, Lin ZY, Narula A, Gingras AC, Blencowe BJ. Mammalian-specific regulation of higher-order hnRNP protein assemblies controls alternative splicing. Cell      2017 Jul 13;170(2):324-339.e23.

  • research highlighted by Nature Review Molecular Cell Biology

 Weatheritt RJ, Sterne-Weiler T, Blencowe BJ. (2016) The ribosome-engaged landscape of alternative splicing. Nat Struct Mol Biol. 2016 Dec;23(12):1117-1123

 Latysheva NS, Oates ME, Maddox L, Flock T, Gough J, Buljan M, Weatheritt RJ, Babu MM. (2016) Molecular Principles of Gene Fusion Mediated Rewiring of Protein Interaction Networks in Cancer. Molecular Cell. 2016 Aug 18;63(4):579-92

 Irimia M, Weatheritt RJ, Ellis JD, Parikshak NN, Gonatopoulos-Pournatzis T,Babor M, Quesnel-Vallières, M, Tapial J, Raj B, O'Hanlon D, Barrios-Rodiles M, Sternberg MJ, Cordes SP, Roth FP, Wrana JL, Geschwind DH, Blencowe BJ. (2014) A highly conserved program of neuronal microexons is misregulatedin autistic brains. Cell. 159(7):1511-23         

  • Perspective in Cell by Yang and Chen, and in EMBO Journal by Darnell.
  • Research highlighted by Nature Review Neuroscience and Faculty of 1000

 Weatheritt RJ, Gibson TJ, Babu MM. (2014) Asymmetric mRNA localization contributes to fidelity and sensitivity of spatially localized systems. Nat Struct Mol Biol. 21(9); 833-9

  • research highlighted by Faculty of 1000 and by

 Van Roey K, Uyar, Weatheritt RJ, Dinkel H, Seiler M, Budd A, Gibson TJ, Davey NE. (2014) Short linear motifs: ubiquitous and functionally diverse protein interaction modules directing cell regulation. Chemical Reviews. 114(13):6733-78

 Van der Lee R, Buljan M*, Lang B*, Weatheritt RJ*, Daughdrill GW, Dunker AK, Fuxreiter M, Gough J, Gsponer J, Jones DT, Kim PM, Kriwacki RW, Oldfield CJ, Pappu RV, Tompa P, Uversky VN, Wright PE, Babu MM. (2014) Classification of Intrinsically Disordered Regions and Proteins. Chemical Reviews 114 (13): 6589-631

 Weatheritt RJ, Babu MM§. (2013) Evolution. The hidden codes that shape protein evolution. Science  342(6164)

 Van Roey K, Dinkel H*, Weatheritt, RJ*, Gibson TJ, Davey NE. (2013) The switches.ELM resource: a compendium of conditional regulatory interfaces within the intrinsically disordered proteome. Science Signaling. 6(269): rs7

 Weatheritt RJ§, Davey NE, Gibson TJ§. (2012) Linear motifs confer functional diversity onto splice variants. Nucleic Acids Res 40, 7123-7131

  •  recommended reading by Nature Review Genetics

More Garvan Publications