Personalised Cancer Therapeutics Lab

Selected Publications

Lau MT, Ghazanfar S, Parkin A, Chou A, Khuong TM, Yang J, Pajic M*, Neely GG*. *Co-corresponding authors. Systematic Functional Identification of Cancer Multi-Drug Resistance Genes. Genome Biology 2020 21(1):27 

ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium. Pan-cancer analysis of whole genomes. Nature 2020 578(7793):82-93 

Cipponi A, Goode DL, Bedo J, McCabe MJ, Pajic M, Croucher DR, Rajal AG, Junankar SR, Saunders DN, Lobachevsky P, Papenfuss AT, Nessem D, Nobis M, Warren SC, Timpson P, Cowley M, Vargas A, Qiu MR, Generali DG, Keerthikumar S, Nguyen U, Corcoran NM, Long GV, Blay J-Y, Thomas DM. mTOR signaling orchestrates stress-induced mutagenesis underpinning adaptive evolution in human cancers. Science 2020 368(6495):1127-1131

Porazinski S, Parkin A, Pajic M. Senior and corresponding author. Rho-ROCK signaling in normal physiology and as a key player in shaping the tumor microenvironment. Adv Exp Med Biol 2020 1223:99-127 Springer Nature

Kryza T, Khan T, Puttick S , Li C , Sokolowski KA, Tse BWC, Cuda T, Lyons N, Gough M, Yin J, Parkin A, Deryugina EI, Quigley JP, Law RHP, Whisstock JC, Riddell AD, Barbour AP, Wyld DK, Thomas PA, Rose S, Snell CE, Pajic M, He Y, Hooper JD. Effective targeting of intact and proteolysed CDCP1 for imaging and treatment of pancreatic ductal adenocarcinoma. Theranostics 2020 10(9):4116 IF 8.1

Parkin A, Man J, Timpson P, Pajic M. Senior and corresponding author. Targeting the complexity of Src signalling in the tumour microenvironment of pancreatic cancer: from mechanism to therapy. FEBS J 2019 286(18):3510-3539

Chou A, Froio D, Nagrial AM, Parkin A, Murphy KJ, Chin VT, Wohl D, Steinmann A, Stark R, Drury A, Walters SN, Vennin C, Burgess A, Pinese M, Chantrill LA, Cowley MJ, Molloy TJ; Australian Pancreatic Cancer Genome Initiative (APGI), Waddell N, Johns A, Grimmond SM, Chang DK, Biankin AV, Sansom OJ, Morton JP, Grey ST, Cox TR, Turchini J, Samra J, Clarke SJ, Timpson P, Gill AJ, Pajic M. Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer. Gut 2018 67(12):2142  

Vennin C, Chin VT, Warren S, Lucas MC, Herrmann D, Melenec P, Walters SN, Magenau A, Allam AH, McCloy RA, Conway JRW, Pinese M, Boulghourjian A, Zaratzian A, Heu C, Nagrial AM, Chou A, Steinmann A, Drury A, Froio D, Giry-Laterriere M, Harris NLE, Mcghee EJ, Whan R, Grey S, Johns AL, Samra JS, Chantrill L, Gill AJ, Biankin AV, APGI, Wang Y, Evans TRJ, Anderson KI, Samuel MS, Burgess A, Sansom OJ, Morton JP, Pajic M*, Timpson P*. * Co-last and co-corresponding authors. Transient tissue ‘priming’ via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy and the onset of the metastatic niche. Science Translational Medicine 2017 9(384). pii: eaai8504.

Pajic M, Froio D, Daly S, Doculara L, Millar EK, Graham P, Drury A, Steinmann A, de Bock CE, Boulghourjian A, Zaratzian A, Carroll SL, Toohey JM, O’Toole SA, Harris AL, Buffa FM, Gee HE, Hollway G, Molloy TJ. miR-139-5p modulates radiotherapy resistance in breast cancer via repression of multiple DNA repair and reactive oxygen species defence gene networks. Cancer Research 2018 78(2):501

Pajic M, Blatter S, Guyader C, Gonggrijp M, Kersbergen A, Sol1 W, Drost R, Jonkers J, Borst P, Rottenberg S. Selected alkylating agents can overcome drug tolerance of G0-1 like tumor cells and eradicate BRCA1-deficient mammary tumors in mice. Clinical Cancer Research 2017 23(22):7020

Vennin C, Murphy K, Cox T, Morton J, Pajic M* and Timpson P*. *  Co-last and co-corresponding authors. Reshaping the tumor stroma: emerging therapies in pancreatic cancer. Gastroenterology 2018 154(4):820-838

Bailey P, Chang DK, Nones K, Johns AL, Patch AM, Gingras MC, Miller DK, Christ AN, Bruxner TJ, Quinn MC, Nourse C, Murtaugh LC, Harliwong I, Idrisoglu S, Manning S, Nourbakhsh E, Wani S, Fink L, Holmes O, Chin V, Anderson MJ, Kazakoff S, Leonard C, Newell F, Waddell N, Wood S, Xu Q, Wilson PJ, Cloonan N, Kassahn KS, Taylor D, Quek K, Robertson A, Pantano L, Mincarelli L, Sanchez LN, Evers L, Wu J, Pinese M, Cowley MJ, Jones MD, Colvin EK, Nagrial AM, Humphrey ES, Chantrill LA, Mawson A, Humphris J, Chou A, Pajic M et al. Genomic analyses identify molecular subtypes of pancreatic cancer. Nature 2016 531(7592):47-52

Waddell N, Pajic M, Patch AM, Chang DK, Kassahn KS, Bailey P, Johns AL, Miller D et al. Whole genomes redefine the mutational landscape of pancreatic cancer. Nature 2015 518(7540):495* Significant national coverage, including interviews with Dr Pajic for SBS and Channel 7 national news.

Alexandrov LB, Nik-Zainal S, Wedge DC, Aparicio S, Behjati S, Biankin AV, Bignell GR, Bolli N, Borg A, Børresen-Dale A-L, Boyault S, Burkhardt B, Butler AP, Caldas C, Davies HR, Desmedt C, Eils R, Eyfjörð JE, Foekens JA, Greaves M, Hosoda F, Hutter B, Ilicic T, Imbeaud S, Imielinsk M, Jäger N, Pajic M. et al. Signatures of mutational processes in human cancer. Nature 2013; 500(7463):415-21.

Chang DK, Johns AL, Scarlett CJ, Pajic M. et al. Molecular Pathological Phenotypes and Outcome in Adenocarcinoma of the Ampulla of Vater. Journal of Clinical Oncology 2013; 31(10):1348-56.

Biankin AV, Waddell N, Kassahn KS, Gingras MC, Muthuswamy LB, Johns AL, Miller DK, Wilson PJ, Patch AM, Wu J, Chang DK, Cowley MJ, Gardiner BB, Song S, Harliwong I, Idrisoglu S, Nourse C, Nourbakhsh E, Manning S, Wani S, Gongora M, Pajic M. et al. Genomic Analysis Reveals Roles for Chromatin Modification and Axon Guidance in Pancreatic Cancer. Nature 2012 491(7424):399-405.

Pajic M, Scarlett CJ, Chang DK et al. Preclinical strategies to define predictive biomarkers for therapeutically relevant cancer subtypes. Human Genetics 2011; 130(1):93

Pajic M, Iyer JK, Kersbergen A, et al. A moderate increase in Mdr1a/1b expression causes in vivo resistance to doxorubicin in a mouse model for hereditary breast cancer  Cancer Research  (2009) 69 16:6396

More Garvan Publications