Swarbrick Lab

Selected Publications

(Bold=corresponding authorships)

Wu, S. Z., G. Al-Eryani, D. Roden, S. Junankar, et al., E. Lim, S. X. Liu, J. Lundeberg, C. Perou and A. Swarbrick (2021) "An integrated multi-omic single-cell and spatial atlas of human breast cancers." Nature Genetics. In Press

Hickey, T.E., Selth, L.A., Chia, K.M., Laven-Law, G., Milioli, H.H., Roden, D., Jindal, S., Hui, M., Finlay-Schultz, J., Ebrahimie, E., et al. Swarbrick, A., Lim, E., Carroll, J., Tilley, W. (2021). "The androgen receptor is a tumor suppressor in estrogen receptor-positive breast cancer" Nature Medicine 27, 310-320

Sunny Z. Wu, D. L. R., Ghamdan Al-Eryani, Nenad Bartonicek, Kate Harvey, Aurélie S. Cazet, Chia-Ling Chan Simon Junankar, Mun N. Hui, Laurence Gluch, Jane Beith, Andrew Parker, Elizabeth Robbins, Davendra Segara, Cindy Mak, Caroline Cooper, Sanjay Warrier, Joseph Powell, Sandra O’Toole, Elgene Lim and Alexander Swarbrick (2021). "Cryopreservation of human cancers conserves tumour heterogeneity for single-cell multi-omics analysis." Genome Medicine 13, 81.

Ginhoux, F. et al (2021) "A Universal annotation of human monocytes and macrophages in human health and disease" Cell Immunity In press

Andersson,A et al, & J. Lundeberg (2021) " Spatial Deconvolution of HER2-positive Breast Tumors Reveals Novel Intercellular Relationships" Nature Communications In Press

Holliday, H., D. Roden, S. Junankar, S. Z. Wu, e. al, J. Visvader, M. Molloy and A. Swarbrick (2021) "Inhibitor of Differentiation 4 (ID4) represses myoepithelial differentiation of mammary stem cells through its interaction with HEB." iScience. 24, 102072

Wu, S. Z., D. Roden, al., E. Lim, S. X. Liu and A. Swarbrick (2020) "Stromal cell diversity associated with immune evasion in human triple-negative breast cancer" EMBO Journal 39, e104063. Featured in a news and views article by Kalluri et al "A map of human breast cancer: new players in stromal‐immune crosstalk" EMBO J 2020

Brockwell, N. K., J. Rautela, K. L. Owen, L. J. Gearing, S. Deb, K. Harvey, A. Spurling, D. Zanker, C. L. Chan, H. E. Cumming, N. Deng, J. M. Zakhour, H. M. Duivenvoorden, T. Robinson, M. Harris, M. White, J. Fox, C. Ooi, B. Kumar, J. Thomson, N. Potasz, A. Swarbrick, P. J. Hertzog, T. J. Molloy, S. O. Toole, V. Ganju and B. S. Parker (2019). "Tumor inherent interferon regulators as biomarkers of long-term chemotherapeutic response in TNBC." NPJ Precis Oncol 3: 21.

Singh, M., G. Al-Eryani, S. Carswell, J. M. Ferguson, J. Blackburn, K. Barton, D. Roden, F. Luciani, T. Giang Phan, S. Junankar, K. Jackson, C. C. Goodnow, M. A. Smith and A. Swarbrick (2019). "High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes." Nat Commun 10(1): 3120.

Cazet, A. S., Hui, M. N., Elsworth, B. L., Wu, S. Z., Roden, D., Chan, C.-L., . . . Swarbrick, A. (2018). Targeting stromal remodeling and cancer stem cell plasticity to overcome chemoresistance in triple negative breast cancer. Nature Communications 9(1): 2897. 

Lin, H. M., Nikolic, I., Yang, J., Castillo, L., Deng, N., Chan, C. L., . . . Swarbrick, A. (2018). MicroRNAs as potential therapeutics to enhance chemosensitivity in advanced prostate cancer. Sci Rep, 8 (1), 7820. doi:10.1038/s41598-018-26050-y

Nikolic, I., Elsworth, B., Dodson, E., Wu, S. Z., Gould, C. M., Mestdagh, P., . . . Swarbrick, A. (2017). Discovering cancer vulnerabilities using high-throughput micro-RNA screening. Nucleic Acids Research, 45 (22), 12657-12670.

Papachristou, E. K., Kishore, K., Holding, A. N., Harvey, K., Roumeliotis, T. I., Chilamakuri, C. S. R., . . . Carroll, J. S. (2018). Quantitative Multiplexed Rapid Immunoprecipitation Mass spectrometry of Endogenous proteins (qPLEX-RIME) for monitoring the Dynamics of Chromatin-Associated Complexes. Nature Communications, Accepted.

Lin HM, Mahon KL, Spielman C, Gurney H, Mallesara G, Stockler MR, Bastick P, Briscoe K, Marx G, Swarbrick A, Horvath LG.  Phase 2 study of circulating microRNA biomarkers in castration-resistant prostate cancer.  Br J Cancer. 2017

Junankar, S., B. L., D.L. Roden, R. Nair, B. Elsworth, D. Gallego-Ortega, P. Lacaze, A. Cazet, I. Nikolic, W. Siang-Teo, J. Yang, A. McFarland, K. Harvey, M.J. Naylor, S.R. Lakhani, P.T. Simpson, A. Raghavendra, J. Saunus, J. Madore, W. Kaplan, C. Ormandy, E.K.A. Millar, S. O'Toole, K. Yun, and A. Swarbrick, ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype Nature Communications, 2015 6:6548.

Nair R, Roden DL, Teo WS, McFarland A, Junankar S, Ye S, Nguyen A, Yang J, Nikolic I, Hui M, Morey A, Shah J, Pfefferle AD, Usary J, Selinger C, Baker LA, Armstrong N, Cowley MJ, Naylor MJ, Ormandy CJ, Lakhani SR, Herschkowitz JI, Perou CM, Kaplan W, O'Toole SA, Swarbrick A. c-Myc and Her2 cooperate to drive a stem-like phenotype with poor prognosis in breast cancer. Oncogene.  Oncogene, 2014. 33(30): p. 3992-4002

O'Toole, S.A., D.A. Machalek, R.F. Shearer, E.K. Millar, R. Nair, P. Schofield, D. McLeod, C.L. Cooper, C.M. McNeil, A. McFarland, A. Nguyen, C.J. Ormandy, M.R. Qiu, B. Rabinovich, L.G. Martelotto, D. Vu, G.E. Hannigan, E.A. Musgrove, D. Christ, R.L. Sutherland, D.N. Watkins, and A. Swarbrick, Hedgehog Overexpression Is Associated with Stromal Interactions and Predicts for Poor Outcome in Breast Cancer. Cancer Research, 2011; 71(11): p. 4002-4014.

Swarbrick, A*., S.L. Woods, A. Shaw, A. Balakrishnan, Y. Phua, A. Nguyen, Y. Chanthery, L. Lim, L.J. Ashton, R.L. Judson, N. Huskey, R. Blelloch, M. Haber, M.D. Norris, P. Lengyel, C.S. Hackett, T. Preiss, A. Chetcuti, C.S. Sullivan, E.G. Marcusson, W. Weiss, N. L'Etoile, and A. Goga*, miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma. Nature Medicine, 2010; 16(10): p. 1134-40. * Co-corresponding authors

Swarbrick, A*., E. Roy, T. Allen, and J.M. Bishop*, Id1 cooperates with oncogenic Ras to induce metastatic mammary carcinoma by subversion of the cellular senescence response. PNAS, 2008; 105(14): p. 5402-5407. *Co-corresponding authors

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