Dr Yanchuan (Yan) Shi

Dr Yanchuan Shi (Yan) obtained her Bachelor’s degree in Medicine in 1990 followed by a Masters' degree in Nutrition in 1993 from the Harbin Medical University, China. Between 1993 and 2000, she worked as a Lecturer/Senior Lecturer for 7 years at Tianjin Medical University, China, where she conducted
Group Leader - Neuroendocrinology

Conjoint/Adjunct Role(s)

Conjoint Senior Lecturer, St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney

Dr Yanchuan Shi (Yan) obtained her Bachelor’s degree in Medicine in 1990 followed by a Masters' degree in Nutrition in 1993 from the Harbin Medical University, China. Between 1993 and 2000, she worked as a Lecturer/Senior Lecturer for 7 years at Tianjin Medical University, China, where she conducted teaching to undergraduates and postgraduates as well as undertook clinical research on nutrition-related diseases such as osteoporosis. In February 2001, she was awarded a competitive WHO fellowship to come to Australia to conduct a one-year research project in osteoporosis within the Division of Clinical Biochemistry/Department of Endocrinology,  IMVS/Royal Adelaide Hospital,  where she was successfully awarded an International Postgraduate Research Scholarship (IPRS) to commence her PhD at UNSW Sydney & Garvan Institute of Medical Research in 2002, investigating the responses of bone cells to the activation of Wnt signaling pathway and vitamin D.

She received her PhD degree in Medicine in 2006 and subsequently started postdoc training at the Eating Disorder Research Lab, Neuroscience Division at the Garvan Institute. She was promoted to Group Leader of Neuroendocrinology Group in 2014, leading her independent research. She is currently a Conjoint Senior Lecturer at St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney. In February 2012, she received her Australian Medical Council (AMC) Certificate after successfully re-qualifying her medical degree in Australia, which allows her to practice medicine in Australia as well as to bridge the gap between basic science  and clinical practice.

Since 2007, she has authored 32 peer-reviewed publications on the top-ranked journals including Cell Metabolism, Nature Communications, Diabetes, Molecular Metabolism, Trends in Endocrinology and MetabolismEndocrinology and Obesity. She has been invited to speak or present at many international, national and local conferences. Her rising standing in NPY research and energy/glucose metabolism has allowed to establish the collaborations within or outside her research field. Her research has been funded by Diabetes Australia (DART grant) and National Health Medical Research Council (NHMRC project grant), in which she is Chief Investigator A (CIA).

She has also demonstrated a strong commitment to research supervision and mentoring. Since 2009, she has supervised/mentored more than 10 research assistants, undergraduates, PhD students and junior postdocs. She is currently recruiting PhD students, Honours student and Undergraduate Research Opportunity Program (UROP) students. 

Research Interests

Neuroendocrine regulation of food intake
Neuroendocrine regulation of energy expenditure
Energy homeostasis
Glucose metabolism
Body composition
Islet function and insulin secretion

Awards and Honours

2017 - Research Excellence Award, Australian Association of Chinese Biomedical Scientists
2005 - Travel Grant, 15th Annual Meeting of the Australian and New Zealand Bone and Mineral Society (ANZBMS), Perth, WA, Australia
2002-2005 - International Postgraduate Research Scholarship (IPRS), University of New South Wales
2001-2002 - WHO Fellowship, (one of 43 winners in all over China awarded by WHO)
1996-1998 - Excellent in Teaching Award, Tianjin Medical University
1986-1990 - Academic Merit Awards, Harbin Medical University
1985-1990 - University Full Scholarships, Harbin Medical University

Education

2012 - AMC Certificate. Australia Medical Council (AMC) - Australia
2006 - PhD. University of New South Wales - Australia
1993 - Master's degree in Nutrition. Harbin Medical University - China
1990 - Bachelar's degree in Medicine. Harbin Medical University - China

Selected Publications

Lau J, Farzi A, Qi Y, Heilbronn R, Mietzsch M, Shi YC*, Herzog H*. CART neurons in the arcuate nucleus and lateral hypothalamic area exert differential controls on energy homeostasis. Molecular Metabolism. Jan 2018  (*Co-corresponding author)

Loh K#, Shi YC#, Walters S#, Bensellam M ,Lee K, Dezaki K, Nakata M, Ip CK, Chan J, Gurzov EN, Thomas HE, Waibei M, Cantley J, Kay TM, Yada T, Laybutt DR, Grey S and Herzog H. Inhibition of Y1 receptor signaling improves islet transplant outcome. Nature Communications. Sep 2017 (# Co-first author).

Lau J, Farzi A, Enriquez RF, Shi YC*, Herzog H*. GPR88 is a critical regulator of feeding and body composition in mice. Scientific Reports. July 2017 (*Co-corresponding author)

Shi YC*, Ip CK, Reed F, Sarruf DA, Wulff BS, Herzog H. Y5 receptor signalling counteracts the anorectic effects of PYY3-36 in diet induced obese mice. J Neuroendocrinol. May 2017 (*Corresponding author)

Sun WW, Li LY, Huang XF, Shi YC, Yang HQ, Song ZY, Lin S. The central mechanism of risperidone-induced hyperprolactinemia. Progress in Neuropsychopharmacol Biol Psychiatry Mar 2017

Worton LE, Shi YC, Smith E, Barry S, Gonda T, Whitehead J, Gardiner EM. Ectodermal-neural cortex 1 isoforms have contrasting effects on MC3T3-E1 osteoblast mineralization and gene expression. J Cellular Biochemistry. Dec 2016 

Lau J, Shi YC*, Herzog H*. Temperature dependence of the control of energy homeostasis requires CART signaling. Neuropeptides. Apr 2016 (*Corresponding author)

Seimon RV, Shi YC, Slack K, Lee K, Fernando HA, Nguyen AD, Zhang L, Lin S, Enriquez RF, Lau J, Herzog H, Sainsbury A. Intermittent Moderate Energy Restriction Improves Weight Loss Efficiency in Diet-Induced Obese Mice. PLoS One. Jan 2016

Shi YC*, Loh K, Bensellam M, Lee K, Zhai L, Lau J, Cantley J, Luzuriaga J, Laybutt DR, Herzog H. Pancreatic PYY is critical in the control of insulin secretion and glucose homeostasis in female mice. Endocrinology 2015 Sep;156(9):3122-3136 (Selected as cover image on the September issue; *As corresponding author)

Loh K, Herzog H* & Shi YC*. Regulation of Energy Homeostasis by the NPY system (Feature Review). Trends in Endocrinology and Metabolism 2015 March; 26(3), 125-35 (*Corresponding author)

Baldock P, Lin S, Zhang L, Karl T, Shi YC, Driessler F, Zengin A, Hörmer B, Lee N, Wong I, Lin E, Enriquez R, Stehrer B, During M, Yulyaningsih E, Zolotukhin S, Ruohonen S, Savontaus E, Sainsbury A, Herzog H. Neuropeptide Y attenuates stress-induced bone loss through suppression of noradrenaline circuits. J Bone Miner Res. 2014 Febuary 18

Yulyaningsih E, Loh K, Lin S, Lau J, Zhang L, Shi YC, Berning BA, Enriquez RF, Driessler F, Macia L, Khor EC, Qi Y, Baldock P, Sainsbury A & Herzog H. Pancreatic polypeptide controls energy homeostasis via Npy6r signaling in the suprachiasmatic nucleus in mice. Cell Metabolism.  2014 January 7; 19(1): 58-72

Shi YC, Lin Z, Lau J, Zhang H, Yagi M, Kanzler I, Sainsbury A, Herzog H & Lin S. PYY3-36 and pancreatic polypeptide induce satiety in an additive manner via distinct hypothalamic dependent pathways in mice. Obesity. 2013 June 26

Shi YC, Lau J, Lin Z, Zhang H, Zhai L, Sperk G, Heilbronn R, Mietzsch M, Weger S, Huang XF, Enriquez RF, Castillo, L., Baldock PA, Zhang L, Sainsbury A, Herzog H & Lin S. Arcuate NPY controls sympathetic output and BAT function via a relay of tyrosine hydroxylase neurons in the PVN. Cell Metabolism. 2013;17(2):236-48

Macia L, Yulyaningsih E, Bijker M, Pangon L, Nguyen AD, Lin S, Shi YC, Zhang L, Mackay F, Sainsbury A, Herzog H. Neuropeptide Y1 receptor in immune cells regulates inflammation and insulin resistance associated with diet-induced obesity. Diabetes. 2012;61(12):3228-38

Wong IP, Driessler F, Khor EC, Shi YC, Hormer B, Nguyen AD, Enriquez RF, Eisman JA, Sainsbury A, Herzog H, Baldock PA. Peptide YY regulates bone remodelling in mice: a link between gut and skeletal biology. PLoS One. 2012;7(&) e40038

Shi YC, Hämmerle C, Lee I-C, Turner N, Nguyen AD, Riepler SJ, Sainsbury A, Herzog H, Zhang L. Adult-onset PYY overexpression in mice reduces food intake and increased lipogenic capacity. Neuropeptides. 2012;46(4):173-82

Zhang L, Nguyen AD, Lee I-C, Yulyaningsih E, Riepler SJ, Stehrer B, Enriquez RF, Lin S, Shi YC, Baldock PA, Sainsbury A, Herzog H. NPY modulates PYY function in the regulation of energy balance and glucose homeostasis Diabetes, Obesity and Metabolism. 2012;14(8):727-36

Shi YC & Baldock P. Central and peripheral mechanisms of the NPY system in the regulation of bone and adipose tissue (Review). Bone. 2012; 50(2):430-6

Shi YC, Lin S, Castillo L, Aljanova A, Enriquez RF, Nguyen AD, Baldock PA, Zhang L, Bijker MS, Macia L, Yulyaningsih E, Zhang H, Lau J, Sainsbury A, Herzog H. Peripheral-specific Y2 receptor knockdown protects mice from high-fat diet-induced obesity. Obesity. 2011; 19(11): 2137-48

Shi YC, Lin S, Wong IP, Baldock PA, Aljanova A, Enriquez RF, Castillo L, Mitchell NF, Ye JM, Zhang L, Macia L, Yulyaningsih E, Nguyen AD, Riepler SJ, Herzog H, Sainsbury A. NPY neuron-specific Y2 receptors regulate adipose tissue and trabecular bone but not cortical bone homeostasis in mice. PLoS One. 2010; 5(6): e11361

Sainsbury A, Shi YC, Zhang L, Aljanova A, Lin Z, Nguyen AD, Herzog H, Lin S. Y4 receptors and pancreatic polypeptide regulate food intake via hypothalamic orexin and brain-derived neurotropic factor dependent pathways. Neuropeptides. 2010;44(3):261-8.

Zhang L, Lee NJ, Nguyen AD, Enriquez RF, Riepler SJ, Stehrer B, Yulyaningsih E, Lin S, Shi YC, Baldock PA, Herzog H, Sainsbury A. Additive actions of the cannabinoid and neupeptide Y systems on adiposity and lipid oxidation. Diabetes Obesity Metabolism. 2010;12(7):591-603.

Lin S, Shi YC, Yulyaningsih E, Aljanova A, Zhang L, Macia L, Nguyen AD, Lin EJ, During MJ, Herzog H, Sainsbury A. Critical role of arcuate Y4 receptors and the melanocortin system in pancreatic polypeptide-induced reduction in food intake in mice. PLoS One. 2009;4(12):e8488.

Shi YC, Worton L, Esteban L, Baldock P, Fong C, Eisman JA, Gardiner EM. Effects of continuous activation of vitamin D and Wnt response pathways on osteoblastic proliferation and differentiation. Bone. 2007; 41(1): 87-96. 

Person portrait

Dr Yanchuan (Yan) Shi