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No association between common chemokine and chemokine receptor gene variants and prostate cancer risk.


There is growing evidence that inflammation and infection play important roles in the aetiology of prostate cancer. As the chemokine network is directly involved in inflammation and infectious diseases, we tested for an association between six common putative functional variants and prostate cancer risk using an Australian case-control study. We measured CCL5 -403G>A, CXCL12 +801G>A, CCR2V64I (G>A), CCR5?32, CX3CR1V249I (G>A) and CX3CR1T280M (C>T) for 815 cases and 738 controls. Of these only CXCL12 +801G>A has previously been tested and found to be associated with prostate cancer risk. We found no significant associations with prostate cancer risk (all P values > 0.4). All per allele odds ratios ranged from 0.96 (95% CI = 0.80 to 1.16) to 1.06 (95% CI = 0.90 to 1.23). This suggests that these common chemokine and chemokine receptor variants do not play a major, if any, role in susceptibility to prostate cancer.

Type Journal
ISBN 1055-9965 (Print)
Authors Petersen, D.C., Severi, G., Hoang, H.N., Carr, E.J.D., Southey, M.C., English, D.R., Hopper, J.L., Giles, G.G.; Hayes, V.M.
Published Date 2008-12-01
Published Volume 7
Published Issue 12
Published Pages 3615-3617
Status Published in-print
DOI 10.1158/1055-9965.EPI-08-0896
URL link to publisher's version
OpenAccess link to author's accepted manuscript version