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The diverse roles of protein kinase C in pancreatic beta-cell function


Members of the serine/threonine PKC (protein kinase C) family perform diverse functions in multiple cell types. All members of the family are activated in signalling cascades triggered by occupation of cell surface receptors, but the cPKC (conventional PKC) and nPKC (novel PKC) isoforms are also responsive to fatty acid metabolites. PKC isoforms are involved in various aspects of pancreatic beta-cell function, including cell proliferation, differentiation and death, as well as regulation of secretion in response to glucose and muscarinic receptor agonists. Recently, the nPKC isoform, PKCepsilon, has also been implicated in the loss of insulin secretory responsiveness that underpins the development of Type 2 diabetes.

Type Journal
ISBN 0300-5127 (Print)
Authors Biden, T. J. Schmitz-Peiffer, C. Burchfield, J. G. Gurisik, E. Cantley, J. Mitchell, C. J. Carpenter, L.
Publisher Name BIOCHEM SOC T
Published Date 2008-11-01 00:00:00
Published Volume 36
Published Issue Pt 5
Published Pages 916-9
Status Published In-print
OpenAccess Link Biden Transactions 360916.pdf