Preparation of Hierarchical Hollow CaCO3 Particles and the Application as Anticancer Drug Carrier
One-pot approach to couple the crystallization of CaCO(3) nanoparticles and the in situ symmetry-breaking assembly of these crystallites into hollow spherical shells was developed under the templating effect of a soluble starch. Further functional study using HP-a as an anticancer drug carrier (DOX) demonstrated its advantages for localizing drug release by the pH value-sensitive structure and enhancing cytotoxicity by increasing cellular uptake, perinuclear accumulation, and nuclear entry.
|Authors||Wei, W. Ma, G. H. Hu, G. Yu, D. McLeish, T. Su, Z. G. Shen, Z. Y.|
|Publisher Name||J AM CHEM SOC|
|Published Date||2008-11-01 00:00:00|
|OpenAccess Link||https://publications.gimr.garvan.org.au/download.php?10143_10419/08 Wei JACS.pdf|