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Preparation of Hierarchical Hollow CaCO3 Particles and the Application as Anticancer Drug Carrier

Abstract

One-pot approach to couple the crystallization of CaCO(3) nanoparticles and the in situ symmetry-breaking assembly of these crystallites into hollow spherical shells was developed under the templating effect of a soluble starch. Further functional study using HP-a as an anticancer drug carrier (DOX) demonstrated its advantages for localizing drug release by the pH value-sensitive structure and enhancing cytotoxicity by increasing cellular uptake, perinuclear accumulation, and nuclear entry.

Type Journal
Authors Wei, W.; Ma, G. H.; Hu, G.; Yu, D.; McLeish, T.; Su, Z. G.; Shen, Z. Y.
Publisher Name JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Published Date 2008-11-01 00:00:00
Published Volume 130
Published Issue 47
Published Pages 15808-10
Status Published in-print
URL link to publisher's version http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18980322
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/10143