Preparation of Hierarchical Hollow CaCO3 Particles and the Application as Anticancer Drug Carrier
One-pot approach to couple the crystallization of CaCO(3) nanoparticles and the in situ symmetry-breaking assembly of these crystallites into hollow spherical shells was developed under the templating effect of a soluble starch. Further functional study using HP-a as an anticancer drug carrier (DOX) demonstrated its advantages for localizing drug release by the pH value-sensitive structure and enhancing cytotoxicity by increasing cellular uptake, perinuclear accumulation, and nuclear entry.
|Authors||Wei, W.; Ma, G. H.; Hu, G.; Yu, D.; McLeish, T.; Su, Z. G.; Shen, Z. Y.|
|Publisher Name||JOURNAL OF THE AMERICAN CHEMICAL SOCIETY|
|Published Date||2008-11-01 00:00:00|
|URL link to publisher's version||http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18980322|
|OpenAccess link to author's accepted manuscript version||https://publications.gimr.garvan.org.au/open-access/10143|