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NIK overexpression amplifies, whereas ablation of its TRAF3-binding domain replaces BAFF:BAFF-R-mediated survival signals in B cells


BAFF-R-dependent activation of the alternative NF-kappaB pathway plays an essential role in mature B cell survival. Mutations leading to overexpression of NIK and deletion of the TRAF3 gene are implicated in human multiple myeloma. We show that overexpression of NIK in mouse B lymphocytes amplifies alternative NF-kappaB activation and peripheral B cell numbers in a BAFF-R-dependent manner, whereas uncoupling NIK from TRAF3-mediated control causes maximal p100 processing and dramatic hyperplasia of BAFF-R-independent B cells. NIK controls alternative NF-kappaB signaling by increasing the protein levels of its negative regulator TRAF3 in a dose-dependent fashion. This mechanism keeps NIK protein levels below detection even when they cause B cell hyperplasia, so that contributions of NIK to B cell pathologies can easily be overlooked.

Type Journal
ISBN 1091-6490 (Electronic)
Authors Sasaki, Y. Calado, D. P. Derudder, E. Zhang, B. Shimizu, Y. Mackay, F. Nishikawa, S. Rajewsky, K. Schmidt-Supprian, M.
Publisher Name PNAS
Published Date 2008-08-05 00:00:00
Published Volume 105
Published Issue 31
Published Pages 10883-8
Status Published In-print
OpenAccess Link Sasaki PNASb10883-8.pdf