Guidance of B Cells by the Orphan GPCR EBI2 Shapes Humoral Immune Responses
Humoral immunity depends on both rapid and long-term antibody production against invading pathogens. Fundamental to this is the generation of spatially distinct extrafollicular plasmablast and follicular germinal center (GC) B cell populations, yet the migratory cues that guide responding B cells to these alternative compartments remain undefined. Here we show that expression of the orphan G protein-coupled receptor Epstein-Barr virus-induced gene 2 (EBI2) by B cells is essential for their movement to extrafollicular sites and the induction of early plasmablast responses. Conversely, downregulation of EBI2 directs B cells to the center of follicles and is required for GC formation. EBI2 therefore provides a previously uncharacterized dimension to B cell migration that is crucial for coordinating rapid versus long-term antibody responses.
|Authors||Gatto, D.; Paus, D.; Basten, A.; Mackay, C.R.; Brink, R.|
|DOI||S1074-7613(09)00313-6 [pii] 10.1016/j.immuni.2009.06.016|
|URL link to publisher's version||http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19615922|
|OpenAccess link to author's accepted manuscript version||https://publications.gimr.garvan.org.au/open-access/10195|