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Guidance of B Cells by the Orphan GPCR EBI2 Shapes Humoral Immune Responses


Humoral immunity depends on both rapid and long-term antibody production against invading pathogens. Fundamental to this is the generation of spatially distinct extrafollicular plasmablast and follicular germinal center (GC) B cell populations, yet the migratory cues that guide responding B cells to these alternative compartments remain undefined. Here we show that expression of the orphan G protein-coupled receptor Epstein-Barr virus-induced gene 2 (EBI2) by B cells is essential for their movement to extrafollicular sites and the induction of early plasmablast responses. Conversely, downregulation of EBI2 directs B cells to the center of follicles and is required for GC formation. EBI2 therefore provides a previously uncharacterized dimension to B cell migration that is crucial for coordinating rapid versus long-term antibody responses.

Type Journal
ISBN 1097-4180 (Electronic)
Authors Gatto, D.; Paus, D.; Basten, A.; Mackay, C.R.; Brink, R.
Publisher Name IMMUNITY
Published Date 2009-08-21
Published Volume 31
Published Pages 259-269
Status Published in-print
DOI S1074-7613(09)00313-6 [pii] 10.1016/j.immuni.2009.06.016
URL link to publisher's version
OpenAccess link to author's accepted manuscript version