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Real time intraoperative confocal laser microscopy-guided surgery


OBJECTIVE: To assess the potential utility of in vivo histologic surface and subsurface imaging in real-time using the Optiscan confocal laser microscope to detect diseased tissue at the time of surgery. SUMMARY BACKGROUND DATA: The goal of surgical treatment of diseases such as cancer is complete microscopic resection of diseased tissue; however, current methods for the assessment of extent of disease at the time of surgery are inadequate. METHODS: We assessed the potential of the Optiscan confocal laser microscope, a new device developed for real-time in vivo histologic surface and subsurface imaging during surgery. RESULTS: Intravenous Fluorescein Sodium contrast enabled visualization of cellular and architectural morphology of intra-abdominal organs with magnification equivalent to light microscopy and enabled differentiation between normal organs and disease. CONCLUSIONS: Real time intraoperative confocal microscopy has significant potential application in detecting disease, and influencing decision-making at the time of surgery.

Type Journal
ISBN 1528-1140 (Electronic)
Authors Nguyen, N. Q.; Biankin, A. V.; Leong, R. W.; Chang, D. K.; Cosman, P. H.; Delaney, P.; Kench, J. G.; Merrett, N. D.;
Published Date 2009-01-01
Published Volume 249
Published Issue 5
Published Pages 735-7
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version