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Biological determinants of resistance to tamoxifen treatment in breast cancer

Abstract

Endocrine therapies targetting estrogen action (antiestrogens and aromatase inhibitors) decrease mortality from breast cancer, but their efficacy is limited by intrinsic and acquired therapeutic resistance. Candidate molecular biomarkers and gene expression signatures of tamoxifen response emphasise the importance of deregulation of proliferation and survival signalling in endocrine resistance. However, to date they have offered limited insights into the specific genetic lesions and molecular processes that determine clinical endocrine resistance. The development of large-scale computational and genetic approaches offers the promise of identifying mediators of endocrine resistance that may be exploited as potential therapeutic targets and biomarkers of response in the clinic.

Type Journal
ISBN 1474-1768 (Electronic)
Authors Musgrove, E.A.; Sutherland, R.L.
Responsible Garvan Author
Publisher Name NATURE REVIEWS CANCER
Published Date 2009-09-01
Published Volume 9
Published Issue 9
Published Pages 631-643
Status Published in-print
DOI 10.1038/nrc2713
URL link to publisher's version http://www.nature.com/nrc/journal/v9/n9/full/nrc2713.html
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/10345