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High affinity B cell receptor ligation by cognate antigen induces cytokine-independent isotype switching


The selection of an appropriate immunoglobulin (Ig) isotype is critical for an effective immune response against pathogens. Isotype regulation is sensitive to external signals, particularly cytokines secreted by T helper cells. For example, interleukin (IL)-4 induces isotype switching to IgG1 via a STAT6-dependent signalling pathway. Here, we show that B cell receptor (BCR) ligation also induces IgG1 switching. The extent of switch induction by antigen is affinity-dependent and high affinity antigen binding leads to IgG1 switching levels comparable to those induced by saturating IL-4. However, the antigen-induced IgG1 switch does not require additional cytokine signals and occurs in a STAT6-independent manner. Thus, BCR ligation represents a novel pathway for direct isotype switching leading to IgG1 secretion.

Type Journal
ISBN 0022-1767
Authors Turner, M.L.; Corcoran, L.M.; Brink, R; Hodgkin, P.D.
Published Date 2010-06-15
Published Volume 184
Published Issue 12
Published Pages 6592-9
Status Published in-print
DOI jimmunol.0903437 [pii] 10.4049/jimmunol.0903437
URL link to publisher's version
OpenAccess link to author's accepted manuscript version