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Regulation of TNFRSF and innate immune signalling complexes by TRAFs and cIAPs


There have been a number of recent discoveries relating to the functions of inhibitors of apoptosis (IAPs) and TNF receptor-associated factors (TRAFs) in regulating signalling from TNF receptor superfamily (TNFRSF) members and some tantalizing glimpses into a wider area of in?uence, that of innate immune signalling. Discoveries relating to the function of these ubiquitin E3 ligases in regulating signalling from the eponymous member of the family, TNF-R1, are dealt with superbly in a separate review by Wertz and Dixit and so we will con?ne our discussion to the subset of the TNFRSF that does not contain a death domain (DD). In line with the available data we will divide the review into two parts, the ?rst is restricted to the role of TRAFs 2 and 3 and cIAPs in regulating TNFRSF signalling, whereas the second will be more speculative, asking what role IAPs and TRAFs have in innate immune signalling.

Type Journal
ISBN 1476-5403 (Electronic)
Authors Silke, J.; Brink, R.:
Published Date 2010-01-01
Published Volume 17
Published Issue 1
Published Pages 35-45
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version