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Invariant natural killer (iNK) T cell deficiency in patients with common variable immunodeficiency


Common variable immunodeficiency (CVID) is a B cell immunodeficiency disorder characterized frequently by failure of memory B cell development and antibody secretion. A unifying cellular pathogenesis for CVID has not been forthcoming, but given the immunoregulatory role of invariant NK (iNK) T cells and their absence in several other immunodeficiencies, we quantified these cells in the blood of 58 CVID patients. There was a marked decrease in the proportion of iNK T cells in CVID patients compared with controls. This was particularly notable in those with low isotype-switched memory B cells, but subset analysis demonstrated no difference when stratified by specific clinical features. We propose that the decreased proportion of iNK T cells in CVID might be linked to the failure of memory B cell generation, which may contribute to reduced antibody production in these patients.

Type Journal
ISBN 1365-2249 (Electronic)
Authors Fulcher, D. A.; Avery, D. T.; Fewings, N. L.; Berglund, L. J.; Wong, S.; Riminton, D. S.; Adelstein, S.; Tangye, S. G.;
Published Date 2009-09-01
Published Volume 157
Published Issue 3
Published Pages 365-9
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version