Invariant natural killer (iNK) T cell deficiency in patients with common variable immunodeficiency
Common variable immunodeficiency (CVID) is a B cell immunodeficiency disorder characterized frequently by failure of memory B cell development and antibody secretion. A unifying cellular pathogenesis for CVID has not been forthcoming, but given the immunoregulatory role of invariant NK (iNK) T cells and their absence in several other immunodeficiencies, we quantified these cells in the blood of 58 CVID patients. There was a marked decrease in the proportion of iNK T cells in CVID patients compared with controls. This was particularly notable in those with low isotype-switched memory B cells, but subset analysis demonstrated no difference when stratified by specific clinical features. We propose that the decreased proportion of iNK T cells in CVID might be linked to the failure of memory B cell generation, which may contribute to reduced antibody production in these patients.
|Authors||Fulcher, D. A.; Avery, D. T.; Fewings, N. L.; Berglund, L. J.; Wong, S.; Riminton, D. S.; Adelstein, S.; Tangye, S. G.;|
|Publisher Name||CLINICAL AND EXPERIMENTAL IMMUNOLOGY|
|URL link to publisher's version||http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19664144|
|OpenAccess link to author's accepted manuscript version||https://publications.gimr.garvan.org.au/open-access/10364|