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Does skeletal muscle oxidative stress initiate insulin resistance in genetically-predisposed individuals?


Reactive oxygen species (ROS) are postulated to be a common trigger of insulin resistance. For example, treatment of adipocytes with either tumor-necrosis factor-alpha or dexamethasone increases ROS before impairing glucose uptake. Similarly, treatment with mitochondria-specific antioxidants preserves insulin sensitivity in animal models of insulin resistance. However, it remains unclear whether ROS contribute to insulin resistance in humans. First-degree relatives (FDRs) of type 2 diabetes subjects are at increased risk of developing insulin resistance and type 2 diabetes. Here we review the documented metabolic impairments in FDRs that could contribute to insulin resistance via increased oxidative stress. We propose that lipotoxic intermediates and lipid peroxides in skeletal muscle interfere with insulin signaling and might cause insulin resistance in these 'at risk' individuals.

Type Journal
ISBN 1879-3061 (Electronic)
Authors Samocha-Bonet, D.; Heilbronn, L.K.; Lichtenberg, D.; Campbell, L.V.
Responsible Garvan Author A/Prof Dorit Samocha-Bonet
Published Date 2010-03-01
Published Volume 21
Published Issue 2
Published Pages 83-88
Status Published in-print
DOI S1043-2760(09)00159-3 [pii] 10.1016/j.tem.2009.09.008
URL link to publisher's version
OpenAccess link to author's accepted manuscript version