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Impaired growth hormone secretion and increased growth hormone-binding protein levels in subfertile males


OBJECTIVE: To evaluate GH secretion in subfertile males. DESIGN: Comparing GH secretion to a GH stimulation test in two different patient groups and in a control group. PATIENTS: Nine oligozoospermic patients, nine asthenozoospermic patients, and nine age- and body mass index-matched fertile males with normal spermograms. INTERVENTION: All subjects underwent an IV arginine GH stimulation test. MAIN OUTCOME MEASURES: Serum levels of FSH, LH, PRL, E2, T, insulin-like growth factor I (IGF-I), and GH-binding protein were measured. RESULTS: Basal levels of GH were similar in all three groups and serum GH increased in all groups after arginine. However, there was a significant difference between the two patient groups and the control group characterized by an impaired GH response in the subfertile patients. Serum FSH and serum GH-binding protein were significantly higher in the patient groups compared with the controls. Serum LH, PRL, T, E2, and IGF-I were similar in all three groups. CONCLUSIONS: This study demonstrates that subfertile men may suffer from relative GH insufficiency, which could have therapeutical implications.

Type Journal
ISBN 0015-0282 (Print)
Authors Ovesen, P.;Jorgensen, J. O.;Kjaer, T.;Ho, K. K.;Orskov, H.;Christiansen, J. S. :
Published Date 1996-01-01
Published Volume 65
Published Issue 1
Published Pages 165-9
Status Published in-print
URL link to publisher's version