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Vitamin D deficiency: the invisible accomplice of metabolic endotoxemia?


The aetiology of obesity is multi-factorial. Recent research has identified a novel association between endotoxaemia (circulating lipopolysaccharide in the systemic circulation) and low-grade inflammation in the adipose organ, which may contribute to obesity. The mechanisms for the low-grade elevation of circulating lipopolysaccharide in obesity are poorly understood. Vitamin D has been increasingly recognised for its pleiotropic actions beyond maintenance of musculoskeletal health. The parathyroid-vitamin D axis is altered in obesity. Circulating vitamin D levels are lower in obese individuals. The regulatory role of vitamin D in the immune system and colonic mucosa may explain the under-appreciated contribution of vitamin D deficiency in the obese to the pathogenesis of endotoxaemia and adipose inflammation. We propose a hypothetical model linking metabolic endotoxaemia with vitamin D deficiency in obesity. A therapeutic approach involving the use of probiotics and vitamin D metabolites in the obese is described.

Type Journal
ISBN 1873-4286 (Electronic)
Authors Lee, P.; Campbell, L. V.;
Garvan Authors Prof Lesley Campbell , Dr Paul Lee
Published Date 2009-10-01 00:00:00
Published Volume 15
Published Issue 23
Published Pages 2751-8
Status Published In-print
OpenAccess Link Lee currPharmDes.pdf