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Neuropeptide Y and sex hormone interactions in humoral and neuronal regulation of bone and fat


The hypothalamus regulates the skeleton and adipose tissue via endocrine mechanisms. Changes in sex steroid levels in menopause and aging are central to the associated changes in bone mass and adiposity. Whereas many of these effects occur via direct actions on osteoblasts or adipocytes, sex hormones can also mediate effects on bone and adipose tissue via interaction with neuronal pathways. A key hypothalamic regulator of bone and adipose tissue is neuropeptide Y (NPY), which coordinately influences these tissues via effects on neuroendocrine and sympathetic nervous output. Better understanding of the interaction between NPY and sex steroids in regulating skeletal and energy homeostasis could lead to more effective treatments for osteoporosis and obesity.

Type Journal
ISBN 1043-2760 (Linking)
Authors Zengin, A.; Zhang, L.; Herzog, H.; Baldock, P. A.; Sainsbury, A.
Responsible Garvan Author (missing name)
Published Date 2010-08-01
Published Volume 21
Published Issue 7
Published Pages 411-8
Status Published in-print
DOI S1043-2760(10)00039-1 [pii] 10.1016/j.tem.2010.02.004
URL link to publisher's version
OpenAccess link to author's accepted manuscript version