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The functional plasticity of T cell subsets


In 1986, Robert Coffman and Timothy Mossman first described the division of CD4(+) T cells into functional subsets, termed T helper 1 (T(H)1) and T(H)2, based on cytokine production, and in doing so unwittingly opened a Pandora's box of complexity and controversy. Although the mechanisms that regulate T(H)1 and T(H)2 cells are now well known, recent descriptions of other CD4(+) T cell subsets--such as regulatory T cells, T follicular helper cells, T(H)17, T(H)22 and most recently T(H)9 and T(H)22 cells--have questioned how we think of T cell subsets and what commitment to a functional T cell subset means. Here, Nature Reviews Immunology asks four leaders in the field their thoughts on the functional plasticity of T cell subsets.

Type Journal
ISBN 1474-1741 (Electronic)
Authors Bluestone, J. A.; Mackay, C. R.; O'Shea, J. J.; Stockinger, B.;
Published Date 2009-01-01
Published Volume 9
Published Issue 11
Published Pages 811-6
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version