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Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling


Effective humoral immunity depends on the support of B cell responses by T follicular helper (Tfh) cells. Although it has been proposed that Tfh cell differentiation requires T-B interactions, the relative contribution of specific populations of Ag-presenting cells remains unknown. We employed three independent strategies that compromised interactions between CD4(+) T cells and activated B cells in vivo. Whereas the expansion of CD4(+) T cells was relatively unaffected, Tfh cell differentiation was completely blocked in all scenarios. Surprisingly, augmenting antigen presentation by non-B cells rescued Tfh cell differentiation, as determined by surface phenotype, gene expression, and germinal center localization. We conclude that although Ag presentation by responding B cells is typically required for the generation of Tfh cells, this does not result from the provision of a unique B cell-derived signal, but rather because responding B cells rapidly become the primary source of antigen.

Type Journal
ISBN 1097-4180 (Electronic) 1074-7613 (Linking)
Authors Deenick, E. K.; Chan, A.; Ma, C. S.; Gatto, D.; Schwartzberg, P. L.; Brink, R.; Tangye, S. G.
Garvan Authors Dr Elissa Deenick , Prof Stuart Tangye
Publisher Name IMMUNITY
Published Date 2010-08-04 00:00:00
Published Volume 33
Published Issue 2
Published Pages 241-253
Status Published In-print
OpenAccess Link Deenick Immunity.pdf