MicroRNAs in common diseases and potential therapeutic applications
1. Evidence gathered in the last few years has revealed microRNAs (miRNAs) fine-tune gene expression and play an instrumental role in various cellular processes including cell growth, differentiation, proliferation and apoptosis. 2. This review summarizes current knowledge of miRNA-pathways in the pathogenesis of cancer, cardiac diseases, neurodegenerative diseases, diabetes, autoimmune/inflammatory diseases and infection. 3. There is a great promise to target miRNAs as a novel approach to treat human diseases. 4. MiRNA-based therapies are being examined in both animal model studies and human clinical trials.
|Authors||Tsai, L. M.; Yu, D.;|
|Publisher Name||CLIN EXP PHARMACOL P|
|Published Date||2010-01-01 00:00:00|