MicroRNAs in common diseases and potential therapeutic applications
1. Evidence gathered in the last few years has revealed microRNAs (miRNAs) fine-tune gene expression and play an instrumental role in various cellular processes including cell growth, differentiation, proliferation and apoptosis. 2. This review summarizes current knowledge of miRNA-pathways in the pathogenesis of cancer, cardiac diseases, neurodegenerative diseases, diabetes, autoimmune/inflammatory diseases and infection. 3. There is a great promise to target miRNAs as a novel approach to treat human diseases. 4. MiRNA-based therapies are being examined in both animal model studies and human clinical trials.
|Authors||Tsai, L. M.; Yu, D.;|
|Responsible Garvan Author|
|Publisher Name||CLIN EXP PHARMACOL P|
|URL link to publisher's version||http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19671070|
|OpenAccess link to author's accepted manuscript version||https://publications.gimr.garvan.org.au/open-access/10573|