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Control systems and decision making for antibody production


This paper synthesizes recent progress toward understanding the integrated control systems and fail-safes that guide the quality and quantity of antibody produced by B cells. We focus on four key decisions: (1) the choice between proliferation or death in perifollicular B cells in the first 3 days after antigen encounter; (2) differentiation of proliferating perifollicular B cells into extrafollicular plasma cells or germinal center B cells; (3) positive selection of B cell antigen receptor (BCR) affinity for foreign antigen versus negative selection of BCR affinity for self antigen in germinal center B cells; and (4) survival versus death of antibody-secreting plasma cells. Understanding the engineering of these control systems represents a challenging future step for treating disorders of antibody production in autoimmunity, allergy and immunodeficiency.

Type Journal
ISBN 1529-2908 (Linking)
Authors Goodnow, C.C; Vinuesa, C.G; Randall, K.L.; Mackay, F.; Brink, R.
Responsible Garvan Author Prof Robert Brink
Published Date 2010-07-21
Published Volume 11
Published Issue 8
Published Pages 681-8
Status Published in-print
DOI ni.1900 [pii] 10.1038/ni.1900
URL link to publisher's version
OpenAccess link to author's accepted manuscript version