Control systems and decision making for antibody production
This paper synthesizes recent progress toward understanding the integrated control systems and fail-safes that guide the quality and quantity of antibody produced by B cells. We focus on four key decisions: (1) the choice between proliferation or death in perifollicular B cells in the first 3 days after antigen encounter; (2) differentiation of proliferating perifollicular B cells into extrafollicular plasma cells or germinal center B cells; (3) positive selection of B cell antigen receptor (BCR) affinity for foreign antigen versus negative selection of BCR affinity for self antigen in germinal center B cells; and (4) survival versus death of antibody-secreting plasma cells. Understanding the engineering of these control systems represents a challenging future step for treating disorders of antibody production in autoimmunity, allergy and immunodeficiency.
|Authors||Goodnow, C.C; Vinuesa, C.G; Randall, K.L.; Mackay, F.; Brink, R.|
|Responsible Garvan Author||Prof Robert Brink|
|Publisher Name||NATURE IMMUNOLOGY|
|DOI||ni.1900 [pii] 10.1038/ni.1900|
|URL link to publisher's version||http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20644574|
|OpenAccess link to author's accepted manuscript version||https://publications.gimr.garvan.org.au/open-access/10598|