B-cell tolerance: mechanisms and implications
Advances in our knowledge of the spectrum of B-cell activities combined with the remarkable clinical efficacy of B-cell inhibitors in autoimmunity and transplantation settings serve to re-emphasise the importance of tolerance to self and foreign antigens in the B-cell repertoire. In particular, new information is emerging about the molecular mechanisms involved in B-cell tolerance induction and identification of B-cell selective defects that contribute to the pathogenesis of autoimmune/inflammatory diseases.
|ISBN||1879-0372 (Electronic) 0952-7915 (Linking)|
|Authors||Basten, A.; Silveira, P.A.:|
|Publisher Name||CURRENT OPINION IN IMMUNOLOGY|
|DOI||S0952-7915(10)00110-X [pii] 10.1016/j.coi.2010.08.001|
|URL link to publisher's version||http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20829011|
|OpenAccess link to author's accepted manuscript version||https://publications.gimr.garvan.org.au/open-access/10646|