B-cell tolerance: mechanisms and implications
Advances in our knowledge of the spectrum of B-cell activities combined with the remarkable clinical efficacy of B-cell inhibitors in autoimmunity and transplantation settings serve to re-emphasise the importance of tolerance to self and foreign antigens in the B-cell repertoire. In particular, new information is emerging about the molecular mechanisms involved in B-cell tolerance induction and identification of B-cell selective defects that contribute to the pathogenesis of autoimmune/inflammatory diseases.
|ISBN||1879-0372 (Electronic) 0952-7915 (Linking)|
|Authors||Basten, A.; Silveira, P.A.:|
|Publisher Name||CURR OPIN IMMUNOL|
|Published Date||2010-10-28 00:00:00|
|OpenAccess Link||https://publications.gimr.garvan.org.au/download.php?10646_11187/10 Basten COI_.pdf|