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The role of SAP and SLAM family molecules in the humoral immune response

Abstract

Effective B cell mediated immunity, including the formation of germinal centers and the generation of high affinity memory B cells and long-lived plasma cells, is dependent on help provided by CD4+ T cells. Immunodeficiencies that present with defects in the antibody response have provided us with insight into the molecular mechanisms involved in generation of B cell responses and the provision of T cell help. Once such disorder is XLP, which was found to result from mutations in SH2D1A the gene encoding SAP. Patients with XLP present with humoral defects characterized by hypogammaglobulinemia. We now know that SAP, signaling downstream of multiple members of the SLAM family of cell surface receptors, plays a crucial role in many aspects of this immune response. Here, we discuss the role of SAP in the generation of humoral immunity, particularly T-dependent antibody responses and the generation of germinal centers.

Type Journal
Authors Ma, CS.; Deenick EK.
Responsible Garvan Author Dr Cindy Ma
Publisher Name Annals of the New York Academy of Sciences
Published Date 2011-02-15
Published Volume 1217
Published Pages 32-44
Status Published in-print
URL link to publisher's version http://www.ncbi.nlm.nih.gov/pubmed/21091715
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/10677