IL-6, IL-8 and IL-10 levels in healthy weight and overweight children
BACKGROUND/AIM: In adults, studies have shown that obesity is a chronic low-grade inflammatory state characterized by altered levels of cytokines. Studies in children have mainly focused on C-reactive protein and adiponectin, and there is limited data for other inflammatory markers in healthy weight and overweight children. The aim of this study was to measure IL-6, IL-8 and IL-10 levels in healthy normal weight and overweight children at 8 and 15 years. METHODS: 118 normal weight and overweight children (59 boys) from the Nepean longitudinal study were recruited at age 8 years and followed up at 15 years. Serum IL-6, IL-8 and IL-10 levels were measured at both time-points. RESULTS: At 8 years, we found no significant differences in cytokine levels between normal weight and overweight (owt)/obese (ob) groups. However, at 15 years, owt/ob girls (n = 23) had higher levels of IL-6 (p = 0.04), IL-8 (p = 0.04) and IL-10 (p = 0.03) compared to normal weight girls (n = 36), even after adjustment for puberty; no differences were seen in boys. CONCLUSION:The effects of obesity on IL-6, IL-8 and IL-10 levels vary with age and sex, with owt/ob girls at 15 years showing raised IL-6, IL-8 and IL-10 levels compared to healthy weight girls.
|Authors||Tam, C. S.; Garnett, S. P.; Cowell, C. T.; Heilbronn, L. K.; Lee, J. W.; Wong, M.; Baur, L. A.;|
|Publisher Name||HORM RES PAEDIATR|
|Published Date||2010-01-01 00:00:00|
|OpenAccess Link||https://publications.gimr.garvan.org.au/download.php?10849_11215/10 Tam HormoneRes_.pdf|