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The elusive identity of T follicular helper cells


Follicular helper T (Tfh) cells provide help to B cells and allow formation of long-lived antibody responses. Despite an improved understanding of the molecular program that drives Tfh cell formation, their definition remains elusive: neither follicular homing ability, Bcl-6 expression nor IL-21 secretion are exclusive properties of T cells that help B cells, and not all follicular T cells are B cell helpers. Indeed some follicular T cells appear to be suppressive. Furthermore, Tfh cells evolve during an immune response and B cells that have recently bound antigen, germinal center (GC) B cells and plasmablasts interact with phenotypically distinct Tfh cells. Here we propose that distinction between non-GC Tfh and GC Tfh cells might reconcile emerging controversies on Tfh cytokine secretion and the requirement of T-B cell interactions and SAP expression for Tfh formation.

Type Journal
ISBN 1471-4981 (Electronic) 1471-4906 (Linking)
Authors Yu, D.; Vinuesa, C. G.;
Responsible Garvan Author (missing name)
Published Date 2010-01-01
Published Volume 31
Published Issue 10
Published Pages 377-83
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version