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Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells


Weak T cell antigen receptor (TCR) signals from contact with self ligands act in synergy with antiapoptotic signals induced by interleukin 7 (IL-7) to promote the survival of naive T cells in a resting state. The amount of background TCR signaling in naive T cells is set by post-thymic TCR tuning and operates at an intensity just below that required to induce entry into the cell cycle. Costimulation from higher concentrations of IL-7 and other common gamma-chain cytokines can induce T cells to undergo homeostatic proliferation and conversion into cells with a memory phenotype; many of these memory phenotype cells may be the progeny of cells responding to self antigens. The molecular mechanisms that control the conversion of naive resting T cells into memory-phenotype cells TCR-dependent in normal animals are beginning to be understood.

Authors Sprent, J.; Surh, C. D.
Responsible Garvan Author Prof Jonathan Sprent
Published Date 2011-05-05
Published Volume 131
Published Issue 6
Published Pages 478-84
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version