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NPY receptors as potential targets for anti-obesity drug development


The neuropeptide Y system has proven to be one of the most important regulators of feeding behaviour and energy homeostasis, thus presenting great potential as a therapeutic target for the treatment of disorders such as obesity and at the other extreme, anorexia. Due to the initial lack of pharmacological tools that are active in vivo, functions of the different Y receptors have been mainly studied in knockout and transgenic mouse models. However, over recent years various Y receptor selective peptidic and non-peptidic agonists and antagonists have been developed and tested. Their therapeutic potential in relation to treating obesity and other disorders of energy homeostasis is discussed in this review.

Type Journal
ISBN 1476-5381 (Electronic) 0007-1188 (Linking)
Authors Yulyaningsih, E.; Zhang, L.; Herzog, H.; Sainsbury, A.
Published Date 2011-07-01
Published Volume 163
Published Issue 6
Published Pages 1170-202
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version