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Cyclin D as a therapeutic target in cancer.

Abstract

Cyclin D1, and to a lesser extent the other D-type cyclins, is frequently deregulated in cancer and is a biomarker of cancer phenotype and disease progression. The ability of these cyclins to activate the cyclin-dependent kinases (CDKs) CDK4 and CDK6 is the most extensively documented mechanism for their oncogenic actions and provides an attractive therapeutic target. Is this an effective means of targeting the cyclin D oncogenes, and how might the patient subgroups that are most likely to benefit be identified?

Type Journal
Authors Musgrove, E.A.; Caldon, C.E.; Barraclough, J.; Stone, A.; Sutherland, R.L.
Responsible Garvan Author
Publisher Name NATURE REVIEWS CANCER
Published Date 2011-09-01
Published Volume 11
Published Issue 8
Published Pages 558-72
Status Published in-print
DOI nrc3090 [pii] 10.1038/nrc3090
URL link to publisher's version http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=21734724
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/10994