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Interplay between progesterone and prolactin in mammary development and implications for breast cancer.

Abstract

Progesterone and prolactin remodel mammary morphology during pregnancy by acting on the mammary epithelial cell hierarchy. The roles of each hormone in mammary development have been well studied, but evidence of signalling cross-talk between progesterone and prolactin is still emerging. Factors such as receptor activator of NF?B ligand (RANKL) may integrate signals from both hormones to orchestrate their joint actions on the epithelial cell hierarchy. Common targets of progesterone and prolactin signalling are also likely to integrate their pro-proliferative actions in breast cancer. Therefore, a thorough understanding of the interplay between progesterone and prolactin in mammary development may reveal therapeutic targets for breast cancer. This review summarises our understanding of Pg and PRL action in mammary gland development before focusing on molecular mechanisms of signalling cross-talk and the implications for breast cancer.

Type Journal
Authors Lee, H.J.; Ormandy, C.J.
Publisher Name MOLECULAR AND CELLULAR ENDOCRINOLOGY
Published Date 2012-01-01 00:00:00
Published Volume 357
Published Issue 1-2
Published Pages 101-107
Status Published in-print
DOI 10.1016/j.mce.2011.09.020
URL link to publisher's version http://www.ncbi.nlm.nih.gov/pubmed/21945475
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/10997